{"id":"W3013118819","doi":"10.1001/jamanetworkopen.2020.1617","title":"Assessment of Effectiveness and Safety of Osimertinib for Patients With Intracranial Metastatic Disease","year":2020,"lang":"en","type":"review","venue":"JAMA Network Open","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"University of Toronto","keywords":"Osimertinib; Medicine; Oncology; Internal medicine; Lung cancer; Meta-analysis; Disease; Data extraction; MEDLINE; Epidermal growth factor receptor; Intensive care medicine; Cancer; Erlotinib","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002397243,0.0002286189,0.001730054,0.00003108112,0.00004755588,0.00002289123,0.000125385,0.00004107909,0.00002002711],"category_scores_gemma":[0.00005048599,0.0001414198,0.0001560393,0.0001988836,0.00004890716,0.00007609429,0.0001014831,0.0001036291,3.845065e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009603677,"about_ca_system_score_gemma":0.0008172645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002175054,"about_ca_topic_score_gemma":0.000002371056,"domain_scores_codex":[0.9987436,0.0001840914,0.0004683355,0.0002903533,0.0001735495,0.0001400612],"domain_scores_gemma":[0.9984163,0.0005754668,0.0004912965,0.000213281,0.0001461053,0.0001575382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001793559,0.000442062,0.01023843,0.03896672,0.00324892,0.0000164324,0.00002510819,0.00001999732,1.444722e-8,0.0003515838,0.0001037108,0.9447935],"study_design_scores_gemma":[0.01747914,0.003137401,0.2213085,0.08368706,0.03754504,0.000005591442,0.00001142126,0.0001399911,1.378639e-7,0.0001089647,0.6362209,0.0003558847],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003270511,0.9824274,0.001160981,0.00007018786,0.0001231301,0.0142971,0.001168307,0.000008513067,0.0004172877],"genre_scores_gemma":[0.006784669,0.9808631,0.008834803,0.00004996953,0.0001432862,0.00138088,0.001846911,0.00006630072,0.00003006471],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9444376,"threshold_uncertainty_score":0.5766931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02356055666942507,"score_gpt":0.3912075765100821,"score_spread":0.3676470198406571,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}