{"id":"W3013137224","doi":"10.1038/s41556-020-0499-7","title":"Setting the chromatin stage in oocytes","year":2020,"lang":"en","type":"letter","venue":"Nature Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Demethylase; Reprogramming; Cell biology; Histone; Chromatin; Epigenetics; Demethylation; Maternal to zygotic transition; Biology; Histone methylation; Histone code; Zygote; Chemistry; Embryo; Genetics; Embryogenesis; DNA methylation; Gene; Nucleosome; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0002110017,0.0002911187,0.0002624723,0.00005881386,0.00006936507,0.0000240636,0.0004613683,0.002616144,0.00004110559],"category_scores_gemma":[0.0001919247,0.0002095335,0.0001252859,0.0001186274,0.0001040936,0.000001015808,0.0001967998,0.00248449,0.00002294143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002018793,"about_ca_system_score_gemma":0.00009886584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001792541,"about_ca_topic_score_gemma":0.00003231091,"domain_scores_codex":[0.998327,0.0003275248,0.0002971918,0.0005866435,0.00009887003,0.000362783],"domain_scores_gemma":[0.9991562,0.0001073248,0.0002143493,0.000440564,0.00005122185,0.0000303419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001769132,0.0000113933,0.0009329537,0.0000984333,0.00003126052,0.00004557994,0.00004715316,0.0000212979,0.6859012,0.00001278609,0.3115126,0.001367603],"study_design_scores_gemma":[0.0001801725,0.0001129596,0.0001388243,0.000008648247,0.00001053696,8.073489e-7,0.0000111827,0.00003052094,0.1971166,0.0001595085,0.8020252,0.0002050098],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1495131,0.06834169,0.0002448086,0.7624291,0.002143108,0.001194791,0.0004467721,0.00005672573,0.01562996],"genre_scores_gemma":[0.3631211,0.001487838,0.0007197942,0.6195583,0.006782366,0.00005296331,0.005744919,0.00009007389,0.002442637],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.4905125,"threshold_uncertainty_score":0.9998168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006725005834718497,"score_gpt":0.2518089749991557,"score_spread":0.2450839691644372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}