{"id":"W3013176123","doi":"10.3390/cells9040803","title":"Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in Drosophila","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Defense Threat Reduction Agency; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Biology; Gene knockdown; Insulin receptor; Cell biology; Progenitor cell; Drosophila melanogaster; Insulin; RNA interference; Stem cell; Signal transduction; PTEN; Insulin resistance; Gene; Endocrinology; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005749359,0.0002874167,0.0001368795,0.0003242244,0.000166989,0.0003266933,0.0001430285,0.0001801913,0.0007761309],"category_scores_gemma":[0.00004516335,0.0001713193,0.0002127871,0.0001303118,0.0001614155,0.0001632441,0.0002141283,0.0004376301,0.0002041879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003645585,"about_ca_system_score_gemma":0.0001333999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217014,"about_ca_topic_score_gemma":0.002217495,"domain_scores_codex":[0.9999365,0.000005718889,0.000007490873,0.00001938735,0.00002013556,0.00001076947],"domain_scores_gemma":[0.9999433,0.000004949206,0.00002088368,0.000004381552,0.000006612312,0.00001999646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002587759,0.000002756307,0.0003403526,0.00001928648,0.000002123072,0.00003185692,0.000008360988,0.0000247713,0.998836,0.00006148557,0.00001899051,0.0006282392],"study_design_scores_gemma":[0.00001587936,0.0001039305,0.04386825,0.00001640873,0.00003654063,0.0002910173,0.00007283846,0.001209017,0.9500127,0.00008948977,0.004274203,0.000009664351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899771,0.002445371,0.003306777,0.00008977184,0.00002210741,0.00002259557,0.00123056,0.0000838999,0.002821913],"genre_scores_gemma":[0.9904096,0.001212248,0.002570876,0.0001021673,0.000007644344,0.00003222744,0.001171877,0.00003825775,0.004455036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217014,"threshold_uncertainty_score":0.002645075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911278753770359,"score_gpt":0.2351810361192798,"score_spread":0.2160682485815762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}