{"id":"W3013176123","doi":"10.3390/cells9040803","title":"Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in Drosophila","year":2020,"lang":"en","type":"article","venue":"Cells","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Defense Threat Reduction Agency; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense","keywords":"Biology; Gene knockdown; Insulin receptor; Cell biology; Progenitor cell; Drosophila melanogaster; Insulin; RNA interference; Stem cell; Signal transduction; PTEN; Insulin resistance; Gene; Endocrinology; PI3K/AKT/mTOR pathway; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001418877,0.0001600017,0.0002717853,0.00003431492,0.00001933242,0.00001531477,0.0001237643,0.0001245574,0.000004247907],"category_scores_gemma":[0.00002222789,0.0001454618,0.00003193847,0.00007237354,0.000109053,0.00000489058,0.0001015789,0.0001161333,0.000001115552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003194105,"about_ca_system_score_gemma":0.0000427165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000214841,"about_ca_topic_score_gemma":0.00001707919,"domain_scores_codex":[0.99892,0.00007838508,0.0003336923,0.0003916387,0.00007739254,0.0001989428],"domain_scores_gemma":[0.9996267,0.00001104927,0.00009682888,0.0001073707,0.0000281825,0.000129857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005758141,0.00008113364,0.004070652,0.00005483564,0.000006218241,0.00002161741,0.0009038414,0.00007236587,0.9931342,0.00001163346,0.000003531371,0.001582369],"study_design_scores_gemma":[0.0005534858,0.000644354,0.0137572,0.00001843577,0.00001421966,0.0000101253,0.0002204978,0.000984831,0.9834085,0.0001211338,0.00009320636,0.000174088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980321,0.001598536,0.00006185082,0.00003702325,0.00003132805,0.0002158062,0.00001052714,0.000005075486,0.000007734428],"genre_scores_gemma":[0.9977407,0.0004729499,0.001491658,0.0001643282,0.00009307176,0.000007491893,0.00000811786,0.00001593369,0.000005773766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009725797,"threshold_uncertainty_score":0.5931759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01911278753770359,"score_gpt":0.2351810361192798,"score_spread":0.2160682485815762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}