{"id":"W3013201275","doi":"10.1101/2020.03.28.985986","title":"TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"School of Medicine, University of California, San Diego; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institute on Aging; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Damon Runyon Cancer Research Foundation; University of California, San Diego; NOMIS Stiftung; National Science Foundation","keywords":"Stress granule; Biophysics; Acetylation; Cytoplasm; RNA; Chemistry; Proteasome; Chaperone (clinical); Anisotropy; Crystallography; Biochemistry; Biology; Physics; Messenger RNA; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000122901,0.0001612205,0.0001748845,0.0001608161,0.0001981392,0.0003173112,0.000182169,0.000247132,0.001953447],"category_scores_gemma":[0.0001989872,0.0001810051,0.0001732403,0.0001140345,0.0002317337,0.0002529117,0.0002705565,0.0004084558,0.0009131831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000205504,"about_ca_system_score_gemma":0.0001327452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002283745,"about_ca_topic_score_gemma":0.0002318119,"domain_scores_codex":[0.9999155,0.000007893655,0.000004746654,0.00001935044,0.00004126157,0.00001127616],"domain_scores_gemma":[0.9998819,0.00001890444,0.00004062454,0.00001497188,0.00001963543,0.0000239795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008617815,0.00001019887,0.0003537171,0.00003341246,0.000004916002,0.000131779,0.00002800886,0.0002133422,0.9951869,0.001106794,0.0004196861,0.002425205],"study_design_scores_gemma":[0.00001563995,0.00006976163,0.003154291,0.000005548037,0.000006090782,0.0003660932,0.00003087808,0.004029043,0.9837773,0.0007801783,0.007756573,0.000008576136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956211,0.00143671,0.03404401,0.0004752855,0.0003038426,0.00004556146,0.0005780813,0.0006374922,0.00626798],"genre_scores_gemma":[0.9737989,0.0004999836,0.009845215,0.0001317644,0.00005398268,0.00003250613,0.0008344441,0.0001884227,0.01461474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001953447,"threshold_uncertainty_score":0.006534934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306940965105651,"score_gpt":0.2625506402525361,"score_spread":0.2494812306014796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}