{"id":"W3013240359","doi":"10.1007/s00253-020-10522-1","title":"Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134","year":2020,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Australian Research Council; National Natural Science Foundation of China","keywords":"Polyketide; Bipolaris; Gene cluster; Polyketide synthase; Biology; Candida albicans; Microbiology; Genome; Gene; Fungus; Stereochemistry; Biochemistry; Biosynthesis; Chemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887692,0.0007099007,0.001318254,0.001482595,0.0003325456,0.0009925526,0.0004572717,0.000517074,0.001226804],"category_scores_gemma":[0.0004033516,0.000268773,0.0008821692,0.001824141,0.0001959604,0.0003731578,0.0004953183,0.0006883754,0.0008125636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206337,"about_ca_system_score_gemma":0.0004616758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009491918,"about_ca_topic_score_gemma":0.002108338,"domain_scores_codex":[0.9998431,0.00001332367,0.00001423384,0.00005225207,0.0000554367,0.00002163312],"domain_scores_gemma":[0.9997917,0.00005387831,0.00006304362,0.00001938465,0.00003683654,0.00003523758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006518813,0.0001209564,0.004180958,0.0006270624,0.0001089437,0.0008355001,0.0001566882,0.0008717576,0.9674644,0.0001547573,0.0005980807,0.02422899],"study_design_scores_gemma":[0.0003666228,0.002059253,0.188531,0.00039823,0.002691659,0.009748794,0.001889041,0.01765509,0.6912687,0.001247846,0.08389387,0.0002498792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935574,0.007413413,0.01848188,0.0004447274,0.0000958771,0.0002130058,0.03368533,0.000904096,0.003187688],"genre_scores_gemma":[0.8890208,0.003696262,0.03381752,0.0002032211,0.00004521224,0.00009116199,0.06906825,0.0002782486,0.00377931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001482595,"threshold_uncertainty_score":0.004104078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373285030939569,"score_gpt":0.2064473229476436,"score_spread":0.1927144726382479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}