{"id":"W3013240359","doi":"10.1007/s00253-020-10522-1","title":"Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134","year":2020,"lang":"en","type":"article","venue":"Applied Microbiology and Biotechnology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Australian Research Council; National Natural Science Foundation of China","keywords":"Polyketide; Bipolaris; Gene cluster; Polyketide synthase; Biology; Candida albicans; Microbiology; Genome; Gene; Fungus; Stereochemistry; Biochemistry; Biosynthesis; Chemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001803045,0.0003042597,0.0006906262,0.00009216661,0.0001507737,0.000008326296,0.0003356707,0.000973947,0.0002443743],"category_scores_gemma":[0.00008135429,0.0002031621,0.0001205443,0.0003424454,0.0007665745,0.00001753089,0.0002063413,0.0006883585,0.00003240477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001936452,"about_ca_system_score_gemma":0.0001607614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009085492,"about_ca_topic_score_gemma":0.00003285453,"domain_scores_codex":[0.9983492,0.00006274732,0.0004574423,0.0006679113,0.00004069413,0.0004219688],"domain_scores_gemma":[0.9991157,0.0001157662,0.0002348453,0.0003974909,0.00003855082,0.00009764707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006263706,0.00004099129,0.0004900775,0.00004000178,0.0001775245,0.00001158209,0.0002829218,8.071335e-7,0.980594,0.0001257941,0.00194722,0.01566275],"study_design_scores_gemma":[0.001643663,0.0003296687,0.002064952,0.00002808934,0.0002438601,0.00005099467,0.0002104406,0.000005015851,0.9383202,0.00003509571,0.05683596,0.0002320996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9553049,0.002166437,0.0003848127,0.04073482,0.0001042818,0.0006315898,0.0004992609,0.0001167519,0.00005718082],"genre_scores_gemma":[0.9865138,0.0001875972,0.004685896,0.007891486,0.000333198,0.000001328041,0.0003166492,0.00002617287,0.00004386974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05488874,"threshold_uncertainty_score":0.8284711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373285030939569,"score_gpt":0.2064473229476436,"score_spread":0.1927144726382479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}