{"id":"W3013248105","doi":"10.1038/s41467-020-15383-w","title":"The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis","year":2020,"lang":"en","type":"review","venue":"Nature Communications","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"National Human Genome Research Institute; National Key Research and Development Program of China; School of Medicine, Shanghai Jiao Tong University; Nierstichting; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; National Natural Science Foundation of China; Università degli Studi di Torino; Shanghai Municipal Education Commission; Science and Technology Commission of Shanghai Municipality; Ministero della Salute; KfH-Stiftung Präventivmedizin; Seoul National University; Seoul National University Hospital; National Institute on Minority Health and Health Disparities; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; Kids Kidney Research; Shanghai Jiao Tong University; Halpin Foundation; National Institutes of Health; Kidney Research UK; Rare Diseases Clinical Research Network; Agence Nationale de la Recherche; University of Michigan; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; National Center for Advancing Translational Sciences; Medical Research Council; Nephcure Foundation","keywords":"Genome-wide association study; Locus (genetics); Allele; Genetic architecture; Genetic association; Genetics; Disease; Human leukocyte antigen; Membranous nephropathy; Nephropathy; Kidney disease; Internal medicine; Medicine; Biology; Immunology; Gene; Genotype; Kidney; Quantitative trait locus; Endocrinology; Glomerulonephritis; Antigen; Single-nucleotide polymorphism; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004748466,0.0008564272,0.0006354916,0.001347774,0.0004390311,0.001743673,0.000896419,0.0009803436,0.002624271],"category_scores_gemma":[0.009746881,0.0002802917,0.0007227599,0.0008370632,0.000490808,0.0006963252,0.001083559,0.000908128,0.0004141027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003235148,"about_ca_system_score_gemma":0.0004486666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002295073,"about_ca_topic_score_gemma":0.002462214,"domain_scores_codex":[0.9980337,0.001036975,0.0001600298,0.0003822301,0.0002661075,0.0001208987],"domain_scores_gemma":[0.993676,0.002992557,0.001672251,0.0007022218,0.0005285298,0.0004284702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000444957,0.0001288669,0.9652357,0.00009636314,0.0004665834,0.0003266636,0.00007624937,0.0004700621,0.003240264,0.0003986074,0.0008366751,0.02827914],"study_design_scores_gemma":[0.00009311572,0.0004463069,0.9799461,0.0001451675,0.0007638624,0.001924876,0.0001848284,0.008388766,0.002238536,0.003548151,0.00228405,0.00003629692],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9728751,0.008208551,0.009807639,0.003494066,0.0001907112,0.00004595558,0.0009839688,0.0002615536,0.004132432],"genre_scores_gemma":[0.9954327,0.0007434972,0.002828962,0.0002910514,0.0001421793,0.0000105488,0.0002343832,0.00001154251,0.0003051862],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.004748466,"threshold_uncertainty_score":0.02511257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579352108503462,"score_gpt":0.3130242956834899,"score_spread":0.2972307745984553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}