{"id":"W3013248105","doi":"10.1038/s41467-020-15383-w","title":"The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis","year":2020,"lang":"en","type":"review","venue":"Nature Communications","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"National Human Genome Research Institute; National Key Research and Development Program of China; School of Medicine, Shanghai Jiao Tong University; Nierstichting; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; National Natural Science Foundation of China; Università degli Studi di Torino; Shanghai Municipal Education Commission; Science and Technology Commission of Shanghai Municipality; Ministero della Salute; KfH-Stiftung Präventivmedizin; Seoul National University; Seoul National University Hospital; National Institute on Minority Health and Health Disparities; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; Kids Kidney Research; Shanghai Jiao Tong University; Halpin Foundation; National Institutes of Health; Kidney Research UK; Rare Diseases Clinical Research Network; Agence Nationale de la Recherche; University of Michigan; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; National Center for Advancing Translational Sciences; Medical Research Council; Nephcure Foundation","keywords":"Genome-wide association study; Locus (genetics); Allele; Genetic architecture; Genetic association; Genetics; Disease; Human leukocyte antigen; Membranous nephropathy; Nephropathy; Kidney disease; Internal medicine; Medicine; Biology; Immunology; Gene; Genotype; Kidney; Quantitative trait locus; Endocrinology; Glomerulonephritis; Antigen; Single-nucleotide polymorphism; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009301855,0.0003204491,0.001031579,0.0001294935,0.0002996795,0.00004107165,0.0009077133,0.0004012776,0.000006502418],"category_scores_gemma":[0.0008411568,0.0001961893,0.0004808423,0.0005068213,0.0001650954,0.00001897626,0.0007456375,0.00145101,0.00001804517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003843576,"about_ca_system_score_gemma":0.0004605103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001035854,"about_ca_topic_score_gemma":0.00005476442,"domain_scores_codex":[0.9985314,0.0002073552,0.0004927965,0.0003060775,0.0002598008,0.0002025925],"domain_scores_gemma":[0.9966776,0.0008099921,0.0002867803,0.001730435,0.0002324251,0.0002627112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002899129,0.0000975818,0.000009998328,0.007761417,0.0003832384,0.00002303831,0.0001886168,0.000001252244,0.00005183966,0.0002066533,0.001373923,0.9898735],"study_design_scores_gemma":[0.0001872007,0.0002107588,0.0003626279,0.004870919,0.002332886,0.00008019219,0.00003815914,0.00001366954,0.00002033942,0.00003924537,0.9916558,0.000188217],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006030928,0.9927756,0.00001167947,0.004456549,0.0001390665,0.00188535,0.0004376616,0.00002411308,0.0002096266],"genre_scores_gemma":[0.005903474,0.9917769,0.0008626803,0.0004559257,0.0001845558,0.0005753108,0.0001392749,0.00004859823,0.00005324084],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9902819,"threshold_uncertainty_score":0.8000368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579352108503462,"score_gpt":0.3130242956834899,"score_spread":0.2972307745984553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}