{"id":"W3013248902","doi":"10.1158/2326-6074.tumimm19-a59","title":"Abstract A59: Inhibition of Glycogen Synthase Kinase 3 (GSK-3) synergizes with anti-PD-1 by potentiating tumor-infiltrated CD8+ T-cells","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Fluidigm (Canada); McGill University Health Centre; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Cancer research; CD8; Cytotoxic T cell; Immune checkpoint; Melanoma; Blockade; Immunotherapy; PD-L1; Medicine; Perforin; Tumor microenvironment; Tumor-infiltrating lymphocytes; Immune system; Chemistry; Immunology; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001248819,0.0003661961,0.0003379883,0.0002492606,0.0001168522,0.0002948157,0.0001858371,0.0003115798,0.005571994],"category_scores_gemma":[0.0001001901,0.0001397853,0.0003910688,0.0001503212,0.0002281396,0.0001984039,0.0001676345,0.001085197,0.001020405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002368341,"about_ca_system_score_gemma":0.0003957374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003747913,"about_ca_topic_score_gemma":0.0006190909,"domain_scores_codex":[0.9998615,0.00001717377,0.00001642378,0.00002364249,0.00003950368,0.00004175764],"domain_scores_gemma":[0.9999313,0.000009607604,0.00001364646,0.000007182818,0.000004996381,0.0000332823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001739404,0.0005841498,0.0001593053,0.0001181034,0.00002433128,0.00005930791,0.00001073367,0.0002750576,0.9900612,0.0001633437,0.0009252233,0.005879841],"study_design_scores_gemma":[0.0007368717,0.00830971,0.003790814,0.00002026125,0.00006015474,0.0003110365,0.00002238641,0.001710125,0.9790467,0.00017528,0.005806705,0.000009994524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863496,0.002561681,0.0020122,0.0005130417,0.0004352414,0.000174231,0.001649225,0.0002951029,0.006009622],"genre_scores_gemma":[0.9911497,0.000974556,0.00183209,0.0002148393,0.00004561207,0.0001347427,0.001100357,0.00002543153,0.004522759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005571994,"threshold_uncertainty_score":0.01864016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330822633405862,"score_gpt":0.3029204642800895,"score_spread":0.2696122379460308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}