{"id":"W3013248902","doi":"10.1158/2326-6074.tumimm19-a59","title":"Abstract A59: Inhibition of Glycogen Synthase Kinase 3 (GSK-3) synergizes with anti-PD-1 by potentiating tumor-infiltrated CD8+ T-cells","year":2020,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Fluidigm (Canada); McGill University Health Centre; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Cancer research; CD8; Cytotoxic T cell; Immune checkpoint; Melanoma; Blockade; Immunotherapy; PD-L1; Medicine; Perforin; Tumor microenvironment; Tumor-infiltrating lymphocytes; Immune system; Chemistry; Immunology; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008826827,0.0004200431,0.000791616,0.0003425497,0.0006408424,0.00005002105,0.0006295522,0.0004670811,0.002764256],"category_scores_gemma":[0.0003245961,0.0003642171,0.0001667834,0.0009766939,0.001916908,0.000298062,0.0002148937,0.00155301,0.000400735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001297014,"about_ca_system_score_gemma":0.0006701344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001233895,"about_ca_topic_score_gemma":0.00001412303,"domain_scores_codex":[0.9960064,0.001095415,0.0007747861,0.0007355303,0.0002029201,0.00118491],"domain_scores_gemma":[0.9976586,0.0006894495,0.000382117,0.0005938612,0.0006091619,0.00006682239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006526238,0.000310491,0.0006466456,0.0001329283,0.00100925,0.00009445148,0.0007971599,0.00003354714,0.9808721,0.00006099865,0.005837734,0.003678443],"study_design_scores_gemma":[0.003643037,0.001245067,0.002457934,0.0002891516,0.0000508393,0.00006304296,0.00145521,0.000008033419,0.9757143,0.00001384395,0.01467369,0.0003858979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.946703,0.05008318,0.00005292326,0.001274375,0.0003316654,0.0006201831,0.0003217687,0.0001276594,0.0004852851],"genre_scores_gemma":[0.9955289,0.002897532,0.0000373222,0.0002820081,0.00004432345,0.0001549383,0.0002430537,0.00007829944,0.0007336476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04882592,"threshold_uncertainty_score":0.999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03330822633405862,"score_gpt":0.3029204642800895,"score_spread":0.2696122379460308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}