{"id":"W3013282349","doi":"10.3390/cancers12040824","title":"Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Chromosome instability; Cancer; Aneuploidy; Precision medicine; Disease; Bioinformatics; Genetic heterogeneity; Clinical significance; Medicine; Drug development; Oncology; Biology; Chromosome; Phenotype; Internal medicine; Genetics; Gene; Drug","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006320604,0.0006575342,0.0009551088,0.001664874,0.0002297011,0.000859683,0.0007086385,0.0009626957,0.003790744],"category_scores_gemma":[0.001413286,0.0001594495,0.0004952434,0.001708227,0.0004388873,0.0007931903,0.000553128,0.001513366,0.001413293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007793119,"about_ca_system_score_gemma":0.001116604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188148,"about_ca_topic_score_gemma":0.00229142,"domain_scores_codex":[0.9997697,0.00005103762,0.00002996452,0.00003872649,0.00008819074,0.00002238126],"domain_scores_gemma":[0.9995153,0.0002813027,0.00005113268,0.00001049089,0.0001117528,0.00003006772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005776245,0.00003346798,0.0003008794,0.01194062,0.00008989005,0.0001521459,0.00005491159,0.0003775367,0.0007228464,0.004875394,0.032294,0.9491006],"study_design_scores_gemma":[0.00001111093,0.00007373161,0.001315949,0.005956684,0.000131415,0.001332854,0.00005896791,0.0001014287,0.0002724948,0.003348977,0.987379,0.00001739931],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008771611,0.9981097,0.0001034322,0.0004430259,0.0002064513,0.000002892045,0.00002377442,0.000006680689,0.001016317],"genre_scores_gemma":[0.0006724799,0.9984671,0.0001176458,0.0001813943,0.0001326106,0.000004562702,0.00003154579,0.000001254285,0.000391272],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003790744,"threshold_uncertainty_score":0.01268131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06554407278050493,"score_gpt":0.4204867071862821,"score_spread":0.3549426344057772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}