{"id":"W3013282349","doi":"10.3390/cancers12040824","title":"Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Chromosome instability; Cancer; Aneuploidy; Precision medicine; Disease; Bioinformatics; Genetic heterogeneity; Clinical significance; Medicine; Drug development; Oncology; Biology; Chromosome; Phenotype; Internal medicine; Genetics; Gene; Drug","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295766,0.0002806801,0.0008179403,0.00004562305,0.00005248214,0.00002589381,0.0002303551,0.0003058452,0.00001412104],"category_scores_gemma":[0.0001868936,0.0002418907,0.0001753674,0.0001538217,0.000130122,0.000002173647,0.0002315417,0.0002241193,0.000004855524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005529225,"about_ca_system_score_gemma":0.004781458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006707788,"about_ca_topic_score_gemma":0.001183352,"domain_scores_codex":[0.9983824,0.00005388188,0.000628943,0.0006393002,0.00006609597,0.0002293663],"domain_scores_gemma":[0.9991588,0.00006448297,0.000231517,0.0003316249,0.00004226318,0.0001713139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006056898,0.00001623452,0.009610775,0.0009674144,0.0001325739,0.000002175229,0.00001934904,0.000001811666,0.000002967452,0.00002877554,0.0008529369,0.9883589],"study_design_scores_gemma":[0.000243344,0.00005265294,0.002697306,0.0007400854,0.0001012643,0.000002807958,0.0000051872,8.989779e-7,0.000006470234,0.000008033347,0.9958571,0.0002848982],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001496469,0.9970315,0.00001259006,0.0001124897,0.000301298,0.0006724036,0.000195492,0.00000895035,0.000168813],"genre_scores_gemma":[0.0003388334,0.9978912,0.0003122087,0.0002632681,0.0002534167,0.0006033787,0.0002382094,0.00004179512,0.00005771139],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9950041,"threshold_uncertainty_score":0.9864018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06554407278050493,"score_gpt":0.4204867071862821,"score_spread":0.3549426344057772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}