{"id":"W3013327102","doi":"10.1016/j.cmet.2020.03.004","title":"Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function","year":2020,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":241,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; Uniklinikum Giessen und Marburg; Deutsche Krebshilfe; National Multiple Sclerosis Society; Deutsches Zentrum für Infektionsforschung; Bundesministerium für Bildung und Forschung; Fonds National de la Recherche Luxembourg","keywords":"Cell metabolism; Serine; Function (biology); Glutathione; Metabolism; Cell biology; Glutathione metabolism; Cell function; Biology; Cell; Chemistry; Computational biology; Biochemistry; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002407999,0.0002817184,0.0002957419,0.00007706099,0.0001113833,0.00004954301,0.0002947023,0.0002262666,0.00006744204],"category_scores_gemma":[0.0001199209,0.0002842409,0.0001537623,0.0003481922,0.00003216653,0.00001170251,0.000254661,0.0001637718,0.0001420145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000781831,"about_ca_system_score_gemma":0.00007890885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001860496,"about_ca_topic_score_gemma":0.000004895808,"domain_scores_codex":[0.9981568,0.0001413145,0.0003642304,0.0006645939,0.0003020149,0.0003710268],"domain_scores_gemma":[0.9986705,0.00001271923,0.0001422688,0.0005615823,0.0001741998,0.0004386977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001558131,0.00006168798,0.0001209302,0.00003715559,0.00002402643,0.000002583589,0.0001255337,0.001236366,0.9928151,0.0001412024,0.003517706,0.001761909],"study_design_scores_gemma":[0.0005378359,0.0001220265,0.01051366,0.000002019438,0.00006499411,3.211041e-7,0.00002629921,0.00006693883,0.5904616,0.0001288135,0.3978552,0.0002202727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965785,0.01943108,0.007996973,0.0007025645,0.0007149973,0.000436767,0.00003189011,0.00005143099,0.004849289],"genre_scores_gemma":[0.9905739,0.0008963268,0.002992305,0.001222984,0.001555098,0.00004174137,0.0001530211,0.00006748677,0.002497145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4023535,"threshold_uncertainty_score":0.999961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122675278104663,"score_gpt":0.2157730108185116,"score_spread":0.2035054830080453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}