{"id":"W3013350003","doi":"10.3390/cancers12051260","title":"Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Japan Society for the Promotion of Science; Ryobi Teien Memory Foundation; Suzuken Memorial Foundation","keywords":"MMP3; Tetraspanin; Cell biology; MMP2; Green fluorescent protein; Chemistry; Tumor progression; Cancer research; Biology; Cell; Downregulation and upregulation; Gene; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006025327,0.0001658708,0.0001912675,0.00001869097,0.00004833265,0.00001327941,0.0001941963,0.00007968499,0.0001041813],"category_scores_gemma":[0.00007934329,0.0001734943,0.00007314965,0.0001008782,0.0002167861,0.000005125178,0.000112033,0.00008625857,0.000006032769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005610325,"about_ca_system_score_gemma":0.0004073192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005816013,"about_ca_topic_score_gemma":0.00002465293,"domain_scores_codex":[0.9989985,0.00003534659,0.0002239503,0.0003836479,0.0001252742,0.00023328],"domain_scores_gemma":[0.9993167,0.000007795027,0.0001149899,0.0002555661,0.00006596858,0.000239001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101145,0.000009780651,0.0030004,0.0001006275,0.00006090716,0.00001398934,0.0001779644,0.0004154034,0.9902884,0.00005373331,0.002987728,0.002789862],"study_design_scores_gemma":[0.000573396,0.0001564637,0.001011166,0.00002935227,0.00005820489,0.000004490084,0.0002492055,0.0004392926,0.9618244,0.00003247015,0.03538464,0.0002369891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694539,0.02918048,0.0003445591,0.0003250425,0.0001105562,0.0001578965,0.00008898418,0.00001798429,0.0003206141],"genre_scores_gemma":[0.9973904,0.0009158434,0.0003636069,0.0006394675,0.0003172127,0.00002226366,0.00002458572,0.00003924082,0.0002873606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03239691,"threshold_uncertainty_score":0.7074893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202038009655578,"score_gpt":0.2554718051920716,"score_spread":0.2434514250955158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}