{"id":"W3013350003","doi":"10.3390/cancers12051260","title":"Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles","year":2020,"lang":"en","type":"article","venue":"Cancers","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Japan Society for the Promotion of Science; Ryobi Teien Memory Foundation; Suzuken Memorial Foundation","keywords":"MMP3; Tetraspanin; Cell biology; MMP2; Green fluorescent protein; Chemistry; Tumor progression; Cancer research; Biology; Cell; Downregulation and upregulation; Gene; Biochemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002002358,0.0004447815,0.0003567723,0.000295862,0.000172206,0.0005087088,0.0002669712,0.000464975,0.001650459],"category_scores_gemma":[0.0001875837,0.0002244861,0.000538425,0.0001729194,0.0002916547,0.0003154516,0.0004146346,0.0008789566,0.0006771113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004198102,"about_ca_system_score_gemma":0.0002699832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009265101,"about_ca_topic_score_gemma":0.00104615,"domain_scores_codex":[0.9997146,0.00003844426,0.00004450295,0.00006449367,0.00007748273,0.00006054225],"domain_scores_gemma":[0.9996736,0.00005372797,0.0001127683,0.00004380055,0.00002518674,0.00009103015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004821962,0.00001328142,0.00009465285,0.00002757701,0.000006074938,0.00005611976,0.00001351702,0.0000720988,0.9990093,0.0001164374,0.00003993234,0.0005027246],"study_design_scores_gemma":[0.000008711549,0.00008545093,0.001270196,0.000005845947,0.00001283377,0.0002731182,0.00002513084,0.001189279,0.9946043,0.0000447478,0.002475951,0.000004528194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820195,0.001114016,0.01267448,0.0002254498,0.00008271726,0.00006456241,0.001567906,0.0004961455,0.00175518],"genre_scores_gemma":[0.9895947,0.0005720753,0.003909199,0.00005518391,0.00000652325,0.00006367046,0.001055282,0.0001046726,0.004638786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001650459,"threshold_uncertainty_score":0.005521297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01202038009655578,"score_gpt":0.2554718051920716,"score_spread":0.2434514250955158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}