{"id":"W3013386813","doi":"10.1128/jb.00762-19","title":"Genetic Analysis of Mutacin B-Ny266, a Lantibiotic Active against Caries Pathogens","year":2020,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Bacteriocin; Biology; Lantibiotics; Streptococcus mutans; Operon; Streptococcus sobrinus; Locus (genetics); Antimicrobial peptides; Microbiology; Serine; Genetics; Peptide; Biochemistry; Bacteria; Gene; Escherichia coli; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002298628,0.0003545073,0.0002269308,0.0003074363,0.000133264,0.0002510151,0.0003184267,0.000321227,0.000997179],"category_scores_gemma":[0.0002357716,0.0001172163,0.0003431106,0.0002677456,0.0001704024,0.0001829054,0.0002856111,0.0004605543,0.0003259827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001944592,"about_ca_system_score_gemma":0.0002820674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001310238,"about_ca_topic_score_gemma":0.001076329,"domain_scores_codex":[0.9997622,0.00004765703,0.00003185773,0.00003417067,0.00008362993,0.00004048096],"domain_scores_gemma":[0.9998139,0.00004145782,0.0000566905,0.00001426387,0.00002284195,0.00005082087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101303,0.00006561216,0.0001097871,0.00001558417,0.00000268887,0.00005231721,0.000008002129,0.00005984582,0.9989618,0.00002825243,0.00001264287,0.0005820754],"study_design_scores_gemma":[0.00002768475,0.001259126,0.004661656,0.000009229916,0.0000207795,0.0005072372,0.00005803323,0.001159188,0.9902894,0.00002350071,0.001975914,0.000008123604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955712,0.0004418205,0.002017863,0.00008031108,0.00002155027,0.00006178623,0.0006851052,0.00003505591,0.001085308],"genre_scores_gemma":[0.9859774,0.0006781536,0.006269016,0.00004160573,0.00001080296,0.00004226617,0.002426418,0.00004943395,0.004504893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001310238,"threshold_uncertainty_score":0.003335893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02423353460388488,"score_gpt":0.2876342904672008,"score_spread":0.2634007558633159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}