{"id":"W3013427169","doi":"10.1111/apt.15684","title":"Letter: immunogenicity of infliximab—ready for routine prediction? Authors' reply","year":2020,"lang":"en","type":"letter","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"Immunogenicity; Infliximab; Medicine; Biosimilar; Intensive care medicine; Immunology; Internal medicine; Tumor necrosis factor alpha; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00341649,0.0006928575,0.001400963,0.0009891221,0.00238629,0.002448563,0.001675645,0.03681405,0.007030851],"category_scores_gemma":[0.02977577,0.0006644787,0.001022503,0.0009006239,0.002133799,0.003459427,0.001061551,0.02548461,0.008692648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0026994,"about_ca_system_score_gemma":0.002840185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003410465,"about_ca_topic_score_gemma":0.003379966,"domain_scores_codex":[0.9974096,0.0009239449,0.0003815189,0.0003859164,0.000635726,0.0002632299],"domain_scores_gemma":[0.9885327,0.00701148,0.000572688,0.0002987795,0.002415143,0.001169221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001050531,0.00003370367,0.001227147,0.00004208176,0.00001345004,0.002288895,0.0000987869,0.00007728874,0.0001406675,0.0009101865,0.9881999,0.006862727],"study_design_scores_gemma":[0.000316008,0.0002428446,0.002743898,0.0005343079,0.00007076692,0.0133093,0.0008039387,0.001437669,0.0007120145,0.01437043,0.9652199,0.0002390341],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004609672,0.0007109657,0.00008637706,0.985734,0.01177665,0.000009023307,0.00009895276,0.00004947334,0.001073677],"genre_scores_gemma":[0.004718351,0.0007112129,0.0002850454,0.9673299,0.0240558,0.00003313951,0.00006602525,0.00003086669,0.002769623],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03681405,"threshold_uncertainty_score":0.02352053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02982606425473545,"score_gpt":0.3039235024927864,"score_spread":0.2740974382380509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}