{"id":"W3013478994","doi":"10.1186/s13024-020-00366-8","title":"Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E","year":2020,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"Alberta Innovates; Alberta Innovates Bio Solutions; Michael Smith Health Research BC; Vancouver Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Weston Brain Institute; Canadian Institutes of Health Research; Faculty of Medicine, University of British Columbia; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Cure Alzheimer's Fund","keywords":"Cerebral amyloid angiopathy; Apolipoprotein E; Neurology; Amyloid (mycology); Pathology; Medicine; Lipoprotein; Apolipoprotein B; Neuroscience; Internal medicine; Biology; Dementia; Cholesterol; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242816,0.0002326331,0.0001992874,0.0002019239,0.0001267895,0.0003366743,0.0001496686,0.0003268768,0.001086939],"category_scores_gemma":[0.0001664873,0.0001151616,0.0002470799,0.00008731878,0.0002008111,0.0001665629,0.000112423,0.0004206326,0.0002136063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001499449,"about_ca_system_score_gemma":0.0001041381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000363889,"about_ca_topic_score_gemma":0.0003651457,"domain_scores_codex":[0.9998965,0.0000197861,0.000009050725,0.00002269847,0.00003127705,0.00002066896],"domain_scores_gemma":[0.9998385,0.00003132398,0.0000554513,0.00001956885,0.0000185323,0.00003665691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002699459,0.0001698434,0.0002237192,0.00002891346,0.00001870034,0.0001063009,0.00002472922,0.0001242897,0.9975216,0.00007736941,0.00005584382,0.001378803],"study_design_scores_gemma":[0.0000821457,0.002342737,0.01144125,0.00001420816,0.00007736681,0.0004655462,0.00004680427,0.001650294,0.981152,0.0001629783,0.002553982,0.00001075863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953816,0.001090182,0.002490741,0.00006451345,0.00005916164,0.00001840751,0.00007792464,0.00007204597,0.0007453267],"genre_scores_gemma":[0.9960912,0.0005024676,0.001828213,0.00004710485,0.00001623084,0.00002858702,0.0001434478,0.00001595602,0.0013268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086939,"threshold_uncertainty_score":0.003636181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579451816852171,"score_gpt":0.2460523493891825,"score_spread":0.2302578312206608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}