{"id":"W3013478994","doi":"10.1186/s13024-020-00366-8","title":"Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E","year":2020,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"Alberta Innovates; Alberta Innovates Bio Solutions; Michael Smith Health Research BC; Vancouver Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Weston Brain Institute; Canadian Institutes of Health Research; Faculty of Medicine, University of British Columbia; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Cure Alzheimer's Fund","keywords":"Cerebral amyloid angiopathy; Apolipoprotein E; Neurology; Amyloid (mycology); Pathology; Medicine; Lipoprotein; Apolipoprotein B; Neuroscience; Internal medicine; Biology; Dementia; Cholesterol; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001392768,0.0002734752,0.0003827665,0.0001681593,0.00004867986,0.00005041345,0.0001066391,0.0001187794,0.00003700669],"category_scores_gemma":[0.0001556513,0.0002764206,0.0001324264,0.0007183941,0.00003962495,0.0001356726,0.00005545956,0.0002499949,0.00006393407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000998086,"about_ca_system_score_gemma":0.0001201272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136793,"about_ca_topic_score_gemma":0.00005533246,"domain_scores_codex":[0.9977193,0.0002315565,0.0003902884,0.0006548396,0.0005441604,0.0004598075],"domain_scores_gemma":[0.9990432,0.00001095326,0.00006276093,0.0004076752,0.00008001393,0.0003954546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002626776,0.0004568021,0.002195813,0.00006123695,0.0002923913,0.000534117,0.0002911169,0.0002412828,0.9929828,0.00004468309,0.000394402,0.002242681],"study_design_scores_gemma":[0.003271546,0.000382468,0.02463025,0.00002992777,0.0001011262,0.000008353186,0.00001813706,0.008331001,0.9628718,0.00009226659,0.00004297209,0.0002200969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989773,0.002103973,0.0006977248,0.005994809,0.00003138917,0.001282819,0.00002441803,0.00007897891,0.0000128625],"genre_scores_gemma":[0.9975157,0.00007580862,0.0004977582,0.001339701,0.00007505874,0.0001726527,0.0002603309,0.00005530925,0.000007657221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03011094,"threshold_uncertainty_score":0.9999688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579451816852171,"score_gpt":0.2460523493891825,"score_spread":0.2302578312206608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}