{"id":"W3013534036","doi":"10.1016/j.celrep.2020.02.098","title":"The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; European Regional Development Fund; Canada Research Chairs; Agence Nationale de la Recherche; Fundação para a Ciência e a Tecnologia; Seventh Framework Programme; Department of Biotechnology, Ministry of Science and Technology, India; National Institutes of Health; Case Western Reserve University; Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa; Foundation for the National Institutes of Health","keywords":"Leishmania donovani; Biology; Lipogenesis; Lipid metabolism; Cell biology; Innate immune system; Myeloid; Sterol regulatory element-binding protein; PI3K/AKT/mTOR pathway; mTORC2; Immune system; Cancer research; Immunology; Transcription factor; mTORC1; Signal transduction; Biochemistry; Gene; Leishmaniasis; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008044024,0.0001751824,0.0004415191,0.00008590237,0.000149781,0.00001791043,0.0001000209,0.00007866367,0.0001177426],"category_scores_gemma":[0.00369081,0.0001297239,0.0001448825,0.00061268,0.0002037873,0.0001436525,0.0001891595,0.0002188914,0.00001377288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001249391,"about_ca_system_score_gemma":0.0001938045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002696512,"about_ca_topic_score_gemma":0.000236764,"domain_scores_codex":[0.997679,0.000100429,0.0007920124,0.0004486847,0.0007050925,0.0002747716],"domain_scores_gemma":[0.9975499,0.0003195402,0.0004958813,0.0006900987,0.0007278941,0.0002166827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00042293,0.0003282372,0.4817019,0.0005392071,0.00008954081,0.00008118682,0.0006962532,0.0000314829,0.5030032,0.00002122193,0.006120533,0.006964188],"study_design_scores_gemma":[0.0003023033,0.0008322047,0.5657607,0.000103223,0.00003963336,0.00003339499,0.0003220025,0.0000862709,0.4255162,0.0001465849,0.006730045,0.0001274312],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922401,0.000158219,0.0005790841,0.001137168,0.0001226884,0.0008979387,0.000002670875,0.00005691334,0.004805199],"genre_scores_gemma":[0.9989131,0.0001820696,0.0002817917,0.0001242189,0.0001528491,0.00003086928,0.00001013343,0.00002212626,0.0002828279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08405878,"threshold_uncertainty_score":0.5289989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.028857008925143,"score_gpt":0.2925700625810858,"score_spread":0.2637130536559428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}