{"id":"W3013534036","doi":"10.1016/j.celrep.2020.02.098","title":"The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; European Regional Development Fund; Canada Research Chairs; Agence Nationale de la Recherche; Fundação para a Ciência e a Tecnologia; Seventh Framework Programme; Department of Biotechnology, Ministry of Science and Technology, India; National Institutes of Health; Case Western Reserve University; Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa; Foundation for the National Institutes of Health","keywords":"Leishmania donovani; Biology; Lipogenesis; Lipid metabolism; Cell biology; Innate immune system; Myeloid; Sterol regulatory element-binding protein; PI3K/AKT/mTOR pathway; mTORC2; Immune system; Cancer research; Immunology; Transcription factor; mTORC1; Signal transduction; Biochemistry; Gene; Leishmaniasis; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549568,0.0002784371,0.000244326,0.0002943189,0.0001335413,0.0002417794,0.0001302571,0.0002302649,0.002069737],"category_scores_gemma":[0.0001093646,0.000144894,0.0001595205,0.0001138829,0.0002595083,0.000158669,0.0001893316,0.0006716977,0.0002326822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002286492,"about_ca_system_score_gemma":0.000193032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004036814,"about_ca_topic_score_gemma":0.0006911686,"domain_scores_codex":[0.9998403,0.00003582121,0.00001288036,0.00002800661,0.0000298397,0.00005326879],"domain_scores_gemma":[0.9998966,0.00001075202,0.00003054346,0.000008118837,0.000009452616,0.00004459969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000272729,0.00006511433,0.0003340516,0.00003588326,0.000005019599,0.00002335046,0.000008897575,0.00001848908,0.9981329,0.00005896879,0.00005207522,0.0009925764],"study_design_scores_gemma":[0.00005636151,0.001127022,0.01221716,0.00001279121,0.00002827755,0.0003674712,0.00005820266,0.0005052977,0.9823299,0.00008450012,0.003205667,0.000007461793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941702,0.001609693,0.001695323,0.0003095037,0.00007116026,0.00003399267,0.0004445631,0.00009160452,0.001573992],"genre_scores_gemma":[0.9966773,0.0005993068,0.0007102905,0.00007674281,0.00001379178,0.00003863142,0.0003747899,0.000009329982,0.001499803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002069737,"threshold_uncertainty_score":0.006923974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.028857008925143,"score_gpt":0.2925700625810858,"score_spread":0.2637130536559428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}