{"id":"W3013575560","doi":"10.1158/1078-0432.ccr-19-1714","title":"Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Blood Cancer UK; Cancer Research UK; Canadian Institute for Theoretical Astrophysics","keywords":"Immune system; CD8; Multiple myeloma; Bone marrow; Immunology; Medicine; FOXP3; IL-2 receptor; Cytotoxic T cell; T cell; Cancer research; Biology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221932,0.000291544,0.0003090565,0.0004698439,0.0002506399,0.0003002764,0.0001852206,0.0002817371,0.001380621],"category_scores_gemma":[0.0005420669,0.0001276911,0.0001602121,0.0002750068,0.0001879092,0.0001654973,0.0002070542,0.0003903169,0.0001481875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001582098,"about_ca_system_score_gemma":0.0001275726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004367372,"about_ca_topic_score_gemma":0.0004877676,"domain_scores_codex":[0.9998894,0.00001987572,0.00001174885,0.00003564134,0.00002380006,0.00001942986],"domain_scores_gemma":[0.9996605,0.00006550407,0.0001471742,0.00001757423,0.00003013916,0.00007906305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009289081,0.00006437516,0.9821098,0.00002917671,0.00004226063,0.0003118156,0.00006453633,0.0001354473,0.01154085,0.00001958589,0.0001053447,0.004647948],"study_design_scores_gemma":[0.00001985016,0.0003687531,0.9957486,0.000005984909,0.0000428873,0.001908787,0.00006521465,0.0003909686,0.001201285,0.0000336915,0.0002108038,0.000003271519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992896,0.0003729337,0.00009639251,0.00001521419,0.000003398094,0.000003656821,0.00005973304,0.000005948498,0.0001529947],"genre_scores_gemma":[0.9996951,0.00005297898,0.00006248167,0.00000961735,0.000006904798,0.000003061336,0.00007661828,8.104017e-7,0.00009244159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001380621,"threshold_uncertainty_score":0.004618645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07903201766159101,"score_gpt":0.3742623769998158,"score_spread":0.2952303593382248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}