{"id":"W3013587102","doi":"10.1158/1538-7445.sabcs19-p4-10-11","title":"Abstract P4-10-11: PIK3CA status as a predictor of benefit from drugs targeting the PI3K/AKT/mTOR pathway: A meta-analysis of randomized trials","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Medicine; Hazard ratio; Oncology; Randomized controlled trial; Breast cancer; Cancer; Meta-analysis; Internal medicine; Pharmacology; Bioinformatics; Cancer research; Phosphorylation; Confidence interval; Signal transduction; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00798032,0.0003387842,0.005454403,0.0004112367,0.0001345201,0.00004024178,0.0005199867,0.0001442264,0.01857991],"category_scores_gemma":[0.008584638,0.0001969723,0.002766185,0.001994965,0.0007599458,0.0001428289,0.0001894623,0.000556896,0.00001741468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002392907,"about_ca_system_score_gemma":0.001116903,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008904525,"about_ca_topic_score_gemma":0.0002006513,"domain_scores_codex":[0.9928864,0.001453784,0.001875066,0.0006964622,0.002348971,0.0007393641],"domain_scores_gemma":[0.9876826,0.008574933,0.0009918698,0.0008306613,0.00147887,0.0004410116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2808578,0.0003173376,0.0006810519,0.0005839834,0.3654413,0.0000382233,0.02209027,0.00192472,0.314939,0.0005064959,0.001972521,0.01064731],"study_design_scores_gemma":[0.2209878,0.0009393005,0.002660601,0.00033522,0.2789593,0.000001730462,0.01030862,0.001725681,0.4338565,0.003664785,0.04571607,0.0008444859],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9241227,0.05841069,0.0002674663,0.009948337,0.0001077223,0.003320543,0.003169689,0.00006823834,0.000584611],"genre_scores_gemma":[0.9957444,0.0008924484,0.0005936426,0.000389665,0.0005446182,0.001088057,0.0001443607,0.00007068554,0.0005321045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1189175,"threshold_uncertainty_score":0.9997665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.20661264422579,"score_gpt":0.4406368692390121,"score_spread":0.2340242250132221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}