{"id":"W3013587102","doi":"10.1158/1538-7445.sabcs19-p4-10-11","title":"Abstract P4-10-11: PIK3CA status as a predictor of benefit from drugs targeting the PI3K/AKT/mTOR pathway: A meta-analysis of randomized trials","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Medicine; Hazard ratio; Oncology; Randomized controlled trial; Breast cancer; Cancer; Meta-analysis; Internal medicine; Pharmacology; Bioinformatics; Cancer research; Phosphorylation; Confidence interval; Signal transduction; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03667376,0.002978034,0.01798293,0.004841383,0.0006039183,0.004435708,0.002472873,0.002306108,0.007414389],"category_scores_gemma":[0.06165515,0.001359812,0.06318204,0.00588943,0.0009962911,0.002271934,0.001747843,0.003033987,0.0005876889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001877736,"about_ca_system_score_gemma":0.001877695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003013973,"about_ca_topic_score_gemma":0.003269643,"domain_scores_codex":[0.9605258,0.02798254,0.00558823,0.003212981,0.001933845,0.0007565945],"domain_scores_gemma":[0.9156734,0.07319538,0.005986283,0.002518011,0.001859718,0.0007671596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.008374795,0.00002087898,0.008239171,0.05156937,0.9264328,0.000109181,0.00002571992,0.001161924,0.0002317512,0.0001087911,0.0005190914,0.00320653],"study_design_scores_gemma":[0.002803684,0.0003383794,0.00474215,0.002663156,0.9872488,0.00007056248,0.00002202782,0.0009335519,0.0001356855,0.0003736744,0.0006477719,0.0000205161],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07071001,0.9081992,0.008747018,0.001658896,0.001153205,0.001905898,0.005826045,0.0003014504,0.001498312],"genre_scores_gemma":[0.8786391,0.1031072,0.007460735,0.001652902,0.0007409534,0.004211335,0.002889968,0.0001697396,0.001128057],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03667376,"threshold_uncertainty_score":0.1939517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.20661264422579,"score_gpt":0.4406368692390121,"score_spread":0.2340242250132221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}