{"id":"W3013619085","doi":"10.1021/acs.jnatprod.9b01107","title":"Isolation and Synthesis of Veranamine, an Antidepressant Lead from the Marine Sponge <i>Verongula rigida</i>","year":2020,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Complementary and Integrative Health; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health; China Scholarship Council","keywords":"Sponge; Lead (geology); Antidepressant; Isolation (microbiology); Biology; Stereochemistry; Chemistry; Botany; Microbiology; Paleontology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007386124,0.0003596447,0.0002044962,0.0002940611,0.0003498805,0.0002863123,0.0003525704,0.0002859241,0.002637059],"category_scores_gemma":[0.0001193236,0.000157481,0.0002393402,0.0002820809,0.0001752848,0.0004214242,0.0003596783,0.0005236978,0.001152232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001719995,"about_ca_system_score_gemma":0.0004370968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006909746,"about_ca_topic_score_gemma":0.001821427,"domain_scores_codex":[0.9999392,0.0000079233,0.000005750082,0.00001896045,0.00001628669,0.0000118618],"domain_scores_gemma":[0.9999595,0.000003869066,0.000008419565,0.000008399307,0.000007511032,0.00001222884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004735183,0.00003384458,0.0001219532,0.000268282,0.00001520767,0.000602322,0.0000449091,0.0003587806,0.9805554,0.0006891144,0.0003487961,0.01691414],"study_design_scores_gemma":[0.00006308786,0.001684223,0.003945596,0.00009229667,0.00006704015,0.003728476,0.00009391219,0.00138129,0.9327545,0.0008940771,0.05523645,0.00005909635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.79089,0.02031888,0.09670685,0.001233592,0.0004619174,0.001004445,0.004979755,0.001138982,0.08326559],"genre_scores_gemma":[0.9471384,0.006955179,0.03086659,0.0002525095,0.00005001149,0.0001196021,0.003439053,0.0001099968,0.0110686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002637059,"threshold_uncertainty_score":0.008821845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317463850039084,"score_gpt":0.2160866566558037,"score_spread":0.2029120181554129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}