{"id":"W3013660197","doi":"10.1038/s41588-020-0594-5","title":"Minimal phenotyping yields genome-wide association signals of low specificity for major depression","year":2020,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":375,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Cilag; National Institute of Mental Health; Neuraxpharm; Chinese Society of Clinical Oncology; University of Oxford; European Bioinformatics Institute; King's College London; National Institute for Health and Care Research; Fresenius Medical Care North America; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Wellcome Trust; NIHR Maudsley Biomedical Research Centre; GlaxoSmithKline; John Templeton Foundation; Lundbeckfonden; National Science Foundation","keywords":"Biology; Genome-wide association study; Genetics; Computational biology; Genome; Genetic association; Association (psychology); Evolutionary biology; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005246327,0.0006329091,0.0008227504,0.00098525,0.0004354632,0.001169559,0.0003748121,0.0005824124,0.00165107],"category_scores_gemma":[0.01699405,0.0003264504,0.0007173595,0.0009706517,0.001009209,0.0004561163,0.001322656,0.0007445042,0.0003755737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539338,"about_ca_system_score_gemma":0.000349581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009715955,"about_ca_topic_score_gemma":0.001744177,"domain_scores_codex":[0.9939998,0.00328953,0.0003567138,0.001484246,0.000510918,0.0003588116],"domain_scores_gemma":[0.9861195,0.008139458,0.002523542,0.002396306,0.0005209934,0.000300183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001125698,0.00009703533,0.877923,0.0002513086,0.0009327031,0.0008788204,0.000480901,0.002868931,0.06786741,0.004730958,0.001714656,0.04112853],"study_design_scores_gemma":[0.000060483,0.0003449284,0.9538727,0.00006990897,0.0003753003,0.002208648,0.0001668224,0.007900069,0.01390496,0.01741341,0.003648439,0.00003437063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265272,0.000670088,0.06721469,0.0006527368,0.00006610788,0.0001017558,0.001491244,0.0002648813,0.00301121],"genre_scores_gemma":[0.9903284,0.0001082453,0.008557056,0.0001900323,0.00001905185,0.00003536371,0.0005471024,0.00003299415,0.0001818403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005246327,"threshold_uncertainty_score":0.02774554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340830698091785,"score_gpt":0.2620955318321819,"score_spread":0.248687224851264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}