{"id":"W3013691493","doi":"10.1074/jbc.ra119.011029","title":"Calreticulin regulates a switch between osteoblast and chondrocyte lineages derived from murine embryonic stem cells","year":2020,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Calreticulin; Cell biology; Endoplasmic reticulum; NFAT; Biology; Osteoblast; Chondrogenesis; Cellular differentiation; DKK1; Wnt signaling pathway; Stem cell; Signal transduction; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009860896,0.0002854616,0.0001836956,0.0002728946,0.0001403624,0.0002789299,0.0001349216,0.0002320753,0.001475485],"category_scores_gemma":[0.0001097479,0.0001558295,0.0001795742,0.0001528969,0.0002285773,0.0001256835,0.0002331279,0.0004268135,0.0004432256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004523342,"about_ca_system_score_gemma":0.0002817127,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008062603,"about_ca_topic_score_gemma":0.002842177,"domain_scores_codex":[0.9998617,0.00001754972,0.00001484513,0.00003254562,0.00003858642,0.00003460993],"domain_scores_gemma":[0.9998933,0.00001501807,0.00003544758,0.00001144684,0.00001035513,0.00003445088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004934951,0.000007034628,0.0001194148,0.00001325138,0.00000181041,0.00002311307,0.000004235032,0.00001436084,0.9991596,0.00006495481,0.00001715249,0.0005257919],"study_design_scores_gemma":[0.00001441933,0.00005440143,0.004408484,0.000003893726,0.000007599497,0.00009890628,0.00001188973,0.0002519701,0.9931623,0.00002531569,0.001958794,0.000002040853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924533,0.001683303,0.002098517,0.0001249572,0.00004728166,0.00002995207,0.0007669884,0.00008712665,0.002708551],"genre_scores_gemma":[0.9902208,0.000908133,0.002442746,0.00009478226,0.000006891667,0.00003799447,0.0008891912,0.00004529359,0.005354187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475485,"threshold_uncertainty_score":0.00493598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02335163315861135,"score_gpt":0.2317432864055325,"score_spread":0.2083916532469211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}