{"id":"W3013712040","doi":"10.1158/1538-7445.sabcs19-gs5-05","title":"Abstract GS5-05: Primary analysis of NRG-BR005, a phase II trial assessing accuracy of tumor bed biopsies in predicting pathologic complete response (pCR) in patients with clinical/radiological complete response after neoadjuvant chemotherapy (NCT) to explore the feasibility of breast-conserving treatment without surgery","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Biopsy; Breast cancer; Clinical endpoint; Stage (stratigraphy); Radiology; Mammography; Surrogate endpoint; Primary tumor; Breast MRI; Cancer; Clinical trial; Internal medicine; Oncology; Nuclear medicine; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004018181,0.0003219288,0.001341437,0.0003458895,0.0001135434,0.0000216573,0.0003674846,0.0001293635,0.00003113559],"category_scores_gemma":[0.002183281,0.0002066905,0.0003268814,0.001296072,0.0008054117,0.00002373276,0.0003366793,0.0002930897,3.238694e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003074502,"about_ca_system_score_gemma":0.0008036741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005127232,"about_ca_topic_score_gemma":0.0002681449,"domain_scores_codex":[0.9942003,0.002651158,0.001238266,0.0008408746,0.0005478994,0.0005214649],"domain_scores_gemma":[0.9955223,0.002627479,0.0005398762,0.0007029694,0.0004587779,0.0001486428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3685348,0.001312426,0.5723995,0.00004851557,0.0004406458,0.0000299784,0.001317606,0.00009285337,0.05332071,7.264476e-8,0.00001355556,0.002489338],"study_design_scores_gemma":[0.02355155,0.005083138,0.9663467,0.000214606,0.0001312313,0.000002257175,0.0008441382,0.00005388947,0.00356612,0.000002266086,0.00002627054,0.0001777936],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953589,0.0004466494,0.0000108027,0.001717047,0.00003844406,0.001585746,0.000830122,0.000009684341,0.000002601785],"genre_scores_gemma":[0.9988423,0.0001296654,0.0002139032,0.0002177186,0.00006402362,0.0004108957,0.00009229669,0.00002748903,0.000001707773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3939473,"threshold_uncertainty_score":0.8428595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2363181182339992,"score_gpt":0.4518731586365466,"score_spread":0.2155550404025474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}