{"id":"W3013712040","doi":"10.1158/1538-7445.sabcs19-gs5-05","title":"Abstract GS5-05: Primary analysis of NRG-BR005, a phase II trial assessing accuracy of tumor bed biopsies in predicting pathologic complete response (pCR) in patients with clinical/radiological complete response after neoadjuvant chemotherapy (NCT) to explore the feasibility of breast-conserving treatment without surgery","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Biopsy; Breast cancer; Clinical endpoint; Stage (stratigraphy); Radiology; Mammography; Surrogate endpoint; Primary tumor; Breast MRI; Cancer; Clinical trial; Internal medicine; Oncology; Nuclear medicine; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008209845,0.002223138,0.002219205,0.000666358,0.0002944365,0.001093294,0.001752851,0.001414202,0.005156034],"category_scores_gemma":[0.00520179,0.0005717885,0.002503966,0.0005619036,0.001321839,0.000757258,0.0005202102,0.002705564,0.001330925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001757468,"about_ca_system_score_gemma":0.002338568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001844382,"about_ca_topic_score_gemma":0.004013927,"domain_scores_codex":[0.9973956,0.001836829,0.0001021871,0.0002938032,0.0002148902,0.0001567403],"domain_scores_gemma":[0.996318,0.001238562,0.0008910547,0.00040636,0.0002642215,0.0008818233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9318318,0.01661483,0.01325165,0.0008911324,0.001989851,0.00006243165,0.0001099687,0.002304762,0.005426547,0.0001525026,0.001942594,0.02542194],"study_design_scores_gemma":[0.598805,0.3684011,0.02381426,0.00006510728,0.002012369,0.0001372726,0.00005286632,0.003272294,0.001894026,0.0001931513,0.001316384,0.0000362538],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827358,0.001707751,0.001178806,0.0007050305,0.0001704906,0.006089733,0.004442115,0.0003057269,0.002664587],"genre_scores_gemma":[0.9849984,0.0005174037,0.002537322,0.0009968609,0.0001964442,0.003515018,0.005387263,0.00003393004,0.001817376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008209845,"threshold_uncertainty_score":0.04341829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2363181182339992,"score_gpt":0.4518731586365466,"score_spread":0.2155550404025474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}