{"id":"W3013733909","doi":"10.1007/s00439-020-02154-2","title":"Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases","year":2020,"lang":"en","type":"review","venue":"Human Genetics","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Biology; Immunology; IRF8; Immune system; Myeloid; CD14; Antigen presentation; Chemokine; Transcription factor; T cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006057463,0.0008487987,0.001067129,0.00106713,0.000139391,0.0006422743,0.0007311643,0.0008940183,0.002623167],"category_scores_gemma":[0.0005984606,0.0001703069,0.000300378,0.0009454425,0.0004334523,0.0006931115,0.0005579133,0.001623575,0.001343647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005139859,"about_ca_system_score_gemma":0.0007414232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006629248,"about_ca_topic_score_gemma":0.001159768,"domain_scores_codex":[0.9998813,0.00002215338,0.00001460573,0.0000229346,0.00004344476,0.00001554586],"domain_scores_gemma":[0.99978,0.000113669,0.00002939902,0.000006604685,0.00004409824,0.00002620577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001307562,0.00004163995,0.0002257456,0.006052199,0.00007502242,0.0001743856,0.00002351325,0.0003105018,0.002582021,0.003710153,0.03729357,0.9493806],"study_design_scores_gemma":[0.00003291712,0.00006196021,0.001019337,0.002050106,0.0001142382,0.0009833307,0.00003023377,0.0001061569,0.0006027768,0.002350641,0.9926318,0.00001643813],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009301455,0.9984242,0.0001472922,0.0003575763,0.0003234249,0.000002045453,0.0000181184,0.000006887687,0.0006275097],"genre_scores_gemma":[0.0006799321,0.9976758,0.0002461218,0.0002476525,0.0004451547,0.000004822095,0.00004210886,0.000001516371,0.0006568537],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002623167,"threshold_uncertainty_score":0.008775353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861507282400394,"score_gpt":0.2617605213954174,"score_spread":0.2431454485714135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}