{"id":"W3013737316","doi":"10.1101/2020.03.27.20044941","title":"Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200,000 men in UK Biobank","year":2020,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Council Victoria; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; University of Bristol; National Institute for Health and Care Research; Rosetrees Trust; Pancreatic Cancer UK; European Commission; Prostate Cancer Foundation of Australia; Cancer Research Institute; Royal Marsden NHS Foundation Trust; National Cancer Institute; British Heart Foundation; National Human Genome Research Institute; Wellcome Trust; Prostate Cancer Foundation; University Hospitals Bristol NHS Foundation Trust; National Cancer Research Institute; National Health and Medical Research Council; Cancer Research UK","keywords":"Prostate cancer; Mendelian randomization; Medicine; Hazard ratio; Prospective cohort study; Internal medicine; Sex hormone-binding globulin; Oncology; Testosterone (patch); Proportional hazards model; Cancer; Insulin-like growth factor; Gynecology; Endocrinology; Hormone; Androgen; Biology; Confidence interval; Genotype; Genetics; Genetic variants; Growth factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006605514,0.0002631545,0.0003888047,0.0007251138,0.0003416163,0.0006540995,0.0004384682,0.0005090209,0.001950185],"category_scores_gemma":[0.003127449,0.0004905873,0.0003274697,0.001486344,0.0003898528,0.00043907,0.0006906439,0.0003802376,0.000292601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005817772,"about_ca_system_score_gemma":0.0003002978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04292456,"about_ca_topic_score_gemma":0.02568335,"domain_scores_codex":[0.9991868,0.0002979679,0.00008792079,0.0002188556,0.000120755,0.00008772899],"domain_scores_gemma":[0.9985058,0.000318054,0.0007529508,0.0001209026,0.0001394791,0.0001628022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001668763,0.00001857265,0.9978219,0.00001995187,0.00008299439,0.00008693882,0.0001487803,0.00008560091,0.0002370648,0.00001818546,0.0002743174,0.001038799],"study_design_scores_gemma":[0.00001750009,0.00005663915,0.9991321,0.000009979448,0.00003472232,0.0001218843,0.00009970721,0.0002323494,0.00005733036,0.00001534298,0.0002180622,0.000004331265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981633,0.0003589537,0.000184081,0.0000458244,0.000005722636,0.00001001843,0.001077882,0.000006711311,0.0001475279],"genre_scores_gemma":[0.9985486,0.0001384367,0.0001281664,0.00003465541,0.000008510266,0.00001890863,0.0007859808,0.000001932623,0.0003348313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04292456,"threshold_uncertainty_score":0.08534938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03394604510219879,"score_gpt":0.3044340241734267,"score_spread":0.2704879790712279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}