{"id":"W3013739803","doi":"10.1016/j.ajo.2020.03.020","title":"Faster Sensitivity Loss around Dense Scotomas than for Overall Macular Sensitivity in Stargardt Disease: ProgStar Report No. 14","year":2020,"lang":"en","type":"article","venue":"American Journal of Ophthalmology","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Spark Therapeutics; Allergan; University of California, Los Angeles; Telemedicine and Advanced Technology Research Center; Foundation Fighting Blindness; Genentech; Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften; Novartis; Moorfields Eye Hospital NHS Foundation Trust; University of Pennsylvania; Omeros Corporation; Novo Nordisk; Boehringer Ingelheim; Austrian Science Fund; Heidelberg Engineering; Apellis Pharmaceuticals; Medizinische Universität Graz; Medical Research and Materiel Command; Duke Clinical Research Institute; Astellas Pharma; Ionis Pharmaceuticals; Universität Basel; Carl Zeiss Meditec AG; Johns Hopkins University; David Geffen School of Medicine, University of California, Los Angeles; Case Western Reserve University; F. Hoffmann-La Roche; NightstaRx; Sanofi; Karl-Franzens-Universität Graz","keywords":"Microperimetry; Medicine; Stargardt disease; Blind spot; Central scotoma; Ophthalmology; Cohort; Prospective cohort study; Optometry; Surgery; Retinal; Internal medicine; Visual acuity; Artificial intelligence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006226663,0.0002409639,0.0004951856,0.00006903332,0.00004688319,0.00002269946,0.0001127816,0.00008254998,0.00001410432],"category_scores_gemma":[0.0006225383,0.0002248451,0.0002220275,0.0001412389,0.0002615723,0.00001529138,0.00009886573,0.0001693427,0.000005819138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003226554,"about_ca_system_score_gemma":0.0003422891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004028702,"about_ca_topic_score_gemma":0.00001021527,"domain_scores_codex":[0.9981977,0.0002942294,0.0005079962,0.0003979782,0.0002159639,0.0003861249],"domain_scores_gemma":[0.9985138,0.00006252387,0.0005173123,0.0002049,0.0004132473,0.0002882053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006827269,0.0002567884,0.8612362,0.0000852681,0.0002810479,0.03913925,0.0001731626,0.0004069487,0.09003238,0.00001351669,0.0009657502,0.00058238],"study_design_scores_gemma":[0.005799932,0.007414432,0.8733429,0.0001465328,0.0002263459,0.07473712,0.0008142875,0.001003122,0.01712203,0.0004866506,0.01729213,0.001614479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954876,0.000135753,0.001760414,0.001922868,0.0001758223,0.0002916299,0.00002574553,0.000004345583,0.0001957881],"genre_scores_gemma":[0.9963064,0.0000264106,0.002492305,0.000662756,0.000273318,0.000008618776,0.00007920072,0.00003151959,0.0001195012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07291035,"threshold_uncertainty_score":0.9168918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307048475616954,"score_gpt":0.2691433021674006,"score_spread":0.2560728174112311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}