{"id":"W3013752477","doi":"10.1182/blood.2019004116","title":"An intestinal organoid–based platform that recreates susceptibility to T-cell–mediated tissue injury","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; York University; Crohn's and Colitis Foundation; National Institute on Aging; Parker Institute for Cancer Immunotherapy; National Heart, Lung, and Blood Institute; National Cancer Institute; Kenneth Rainin Foundation; Memorial Sloan-Kettering Cancer Center; National Institutes of Health; Stony Wold-Herbert Fund; Japan Society for the Promotion of Science; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Necroptosis; ATG16L1; Organoid; Autophagy; Transplantation; Hematopoietic stem cell transplantation; Biology; Programmed cell death; Cancer research; Immunology; Stem cell; Medicine; Apoptosis; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001635145,0.0001994855,0.0002732273,0.00006299902,0.0001318622,0.00002694209,0.0002680083,0.0001950204,0.001005131],"category_scores_gemma":[0.0001763308,0.0001789507,0.00005180745,0.0002396313,0.00007825991,0.0001611505,0.00006334332,0.0002135484,0.0009399794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002341092,"about_ca_system_score_gemma":0.00008198041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006811808,"about_ca_topic_score_gemma":0.00001491626,"domain_scores_codex":[0.9988778,0.0001076634,0.0002595928,0.000397884,0.00004536192,0.0003117255],"domain_scores_gemma":[0.9993141,0.00009091203,0.00009118023,0.0003374839,0.0000747865,0.00009148948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002470893,0.000486316,0.02053514,0.0000198889,0.00002981034,0.000002635622,0.0003643576,0.000004697617,0.9751354,0.0000121518,0.0007848293,0.002377681],"study_design_scores_gemma":[0.001656621,0.001481283,0.02208561,0.00001935148,0.00006027043,0.000007276511,0.0001284228,0.00003111684,0.9697424,0.0000162193,0.00455476,0.0002166857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975204,0.0003994785,0.0004447584,0.0005538468,0.0001319999,0.0003368002,0.00005475932,0.000206603,0.0003513249],"genre_scores_gemma":[0.9981431,0.000006915888,0.0004394283,0.0006743121,0.00004882097,0.00001815653,0.0005411151,0.00002395756,0.0001041705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005393022,"threshold_uncertainty_score":0.9999081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248590032339813,"score_gpt":0.2541739412285892,"score_spread":0.2293149379946079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}