{"id":"W3013752477","doi":"10.1182/blood.2019004116","title":"An intestinal organoid–based platform that recreates susceptibility to T-cell–mediated tissue injury","year":2020,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; York University; Crohn's and Colitis Foundation; National Institute on Aging; Parker Institute for Cancer Immunotherapy; National Heart, Lung, and Blood Institute; National Cancer Institute; Kenneth Rainin Foundation; Memorial Sloan-Kettering Cancer Center; National Institutes of Health; Stony Wold-Herbert Fund; Japan Society for the Promotion of Science; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"Necroptosis; ATG16L1; Organoid; Autophagy; Transplantation; Hematopoietic stem cell transplantation; Biology; Programmed cell death; Cancer research; Immunology; Stem cell; Medicine; Apoptosis; Cell biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753426,0.0003425445,0.0003154138,0.0003239481,0.0001796593,0.0004546497,0.0002363478,0.0004138858,0.001404182],"category_scores_gemma":[0.0001412169,0.0001219399,0.0002828389,0.0001124605,0.0003587424,0.0002688258,0.0003738628,0.000893123,0.0003807282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550728,"about_ca_system_score_gemma":0.0002160232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001730821,"about_ca_topic_score_gemma":0.0003581658,"domain_scores_codex":[0.9998285,0.00004121288,0.00001112872,0.0000427958,0.00004995078,0.00002645618],"domain_scores_gemma":[0.9998332,0.00002601508,0.00004807423,0.00003912756,0.00001067429,0.00004280731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009942717,0.00005355449,0.0001795375,0.00002630594,0.000005899362,0.00006509956,0.00001881805,0.0002951425,0.9977865,0.0002177259,0.00006036317,0.001191583],"study_design_scores_gemma":[0.00003357009,0.001032376,0.001526096,0.0000134457,0.00002748542,0.0004571013,0.00005037103,0.001554286,0.9906684,0.000140788,0.004486834,0.000009289905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583488,0.000830049,0.0363755,0.0002518102,0.0001187921,0.0001500443,0.0006955893,0.0003494585,0.002880017],"genre_scores_gemma":[0.9811898,0.0003995787,0.01578643,0.00007942181,0.000009410787,0.0001006115,0.0004668765,0.00004866004,0.001919342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404182,"threshold_uncertainty_score":0.004697502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248590032339813,"score_gpt":0.2541739412285892,"score_spread":0.2293149379946079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}