{"id":"W3013752975","doi":"10.1101/2020.03.27.011775","title":"Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast <i>Candida albicans</i>","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Trace Elements in Health","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Université Laval","keywords":"Candida albicans; Biology; Transcriptome; Virulence; Yeast; Mutant; Microbiology; Copper; Transcription factor; Gene; Corpus albicans; Antifungal drug; Fungus; Gene expression; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008693851,0.0002482779,0.0002811342,0.0002950297,0.0002413648,0.0004707299,0.0001259083,0.0001766072,0.0008838919],"category_scores_gemma":[0.0001070471,0.0001110723,0.0003406103,0.0003522906,0.0001191646,0.0001148173,0.0001996653,0.0003712265,0.0002297646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002939263,"about_ca_system_score_gemma":0.0003203062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002355101,"about_ca_topic_score_gemma":0.003019838,"domain_scores_codex":[0.9999077,0.000005429457,0.000004008351,0.00003965855,0.00002081909,0.00002228726],"domain_scores_gemma":[0.9999413,0.0000116821,0.00001531106,0.000006594503,0.00001336022,0.00001172859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001290954,0.00001072924,0.002107819,0.00003798094,0.000007991887,0.00005380731,0.00001949428,0.0001002905,0.9951432,0.00003846432,0.0001678818,0.0021834],"study_design_scores_gemma":[0.00001900747,0.0002820178,0.3895161,0.00002922803,0.0001098509,0.0006408404,0.0004140366,0.006846898,0.5961609,0.0003909664,0.00555942,0.00003072228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910542,0.0006627761,0.002821163,0.0001092269,0.00001915673,0.00001219891,0.004278103,0.0001188764,0.0009242204],"genre_scores_gemma":[0.9865357,0.0006005066,0.003745865,0.0001112809,0.00001596443,0.00002818929,0.006735237,0.00005152237,0.002175709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355101,"threshold_uncertainty_score":0.004682779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0262238458545765,"score_gpt":0.2599846570854285,"score_spread":0.233760811230852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}