{"id":"W3013790199","doi":"10.1136/annrheumdis-2020-eular.5010","title":"OP0277 AURORA PHASE 3 STUDY DEMONSTRATES VOCLOSPORIN STATISTICAL SUPERIORITY OVER STANDARD OF CARE IN LUPUS NEPHRITIS (LN)","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Medicine; Placebo; Lupus nephritis; Internal medicine; Clinical endpoint; Phases of clinical research; Calcineurin; Proteinuria; Surrogate endpoint; Randomized controlled trial; Statistical significance; Clinical trial; Gastroenterology; Disease; Kidney; Transplantation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002226218,0.0006801751,0.001698264,0.0002885058,0.0002937515,0.001007944,0.0006041414,0.0008231508,0.005686061],"category_scores_gemma":[0.001613998,0.0001850037,0.00147645,0.0003003319,0.0007670094,0.0006729327,0.0002844431,0.001935821,0.0008821658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006231177,"about_ca_system_score_gemma":0.001143515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154679,"about_ca_topic_score_gemma":0.003139897,"domain_scores_codex":[0.9992037,0.0004509428,0.00004682422,0.00009131474,0.00008296923,0.00012416],"domain_scores_gemma":[0.9987759,0.0003777826,0.000269067,0.000144655,0.00007385638,0.0003587463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7896337,0.007944978,0.003008831,0.000808928,0.002222402,0.0001060555,0.00006967727,0.0004820254,0.0156158,0.0004430174,0.00386295,0.1758017],"study_design_scores_gemma":[0.4698864,0.4793168,0.03021543,0.0001527825,0.00201173,0.0004422612,0.00008070929,0.0008811642,0.006505457,0.0003599627,0.01010053,0.00004681388],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813234,0.007819654,0.0009959724,0.001141562,0.0003671729,0.0007259774,0.00203219,0.0002724284,0.005321692],"genre_scores_gemma":[0.9894571,0.00295967,0.001384696,0.0008554168,0.0003666132,0.0003859212,0.001669535,0.00003912689,0.002881977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005686061,"threshold_uncertainty_score":0.01902181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04649363614758237,"score_gpt":0.3739298829634106,"score_spread":0.3274362468158283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}