{"id":"W3013790199","doi":"10.1136/annrheumdis-2020-eular.5010","title":"OP0277 AURORA PHASE 3 STUDY DEMONSTRATES VOCLOSPORIN STATISTICAL SUPERIORITY OVER STANDARD OF CARE IN LUPUS NEPHRITIS (LN)","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Aurinia (Canada)","funders":"","keywords":"Medicine; Placebo; Lupus nephritis; Internal medicine; Clinical endpoint; Phases of clinical research; Calcineurin; Proteinuria; Surrogate endpoint; Randomized controlled trial; Statistical significance; Clinical trial; Gastroenterology; Disease; Kidney; Transplantation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003122397,0.0002219939,0.001034609,0.00009890978,0.00004981432,0.0000238721,0.0003512913,0.0000560258,0.0003557296],"category_scores_gemma":[0.002251206,0.0001569389,0.0002031239,0.0004702541,0.0002970053,0.000107528,0.0001899654,0.0001895791,0.000008013358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004693289,"about_ca_system_score_gemma":0.0005518819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002533162,"about_ca_topic_score_gemma":0.00005909914,"domain_scores_codex":[0.9969738,0.0003539468,0.0008886031,0.000314511,0.001115838,0.0003532828],"domain_scores_gemma":[0.9980708,0.0004697783,0.0001979488,0.0005565797,0.0003429405,0.000361942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003502027,0.001526636,0.9696297,0.005796135,0.0002767488,0.0001493277,0.007994765,0.00001316656,0.0001218592,0.0002832596,0.002301688,0.008404705],"study_design_scores_gemma":[0.04989447,0.02189397,0.7401973,0.01757196,0.001309889,0.0005897168,0.1542704,0.002723382,0.007537399,0.002263163,0.0005936248,0.001154692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923721,0.003540911,0.0000207383,0.00108963,0.0001065001,0.001594548,0.001116132,0.00002865156,0.0001307968],"genre_scores_gemma":[0.9993442,0.0002804275,0.0001272169,0.00009451634,0.00002875819,0.00004250469,0.00002654861,0.00002970595,0.00002613196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2294324,"threshold_uncertainty_score":0.6399784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04649363614758237,"score_gpt":0.3739298829634106,"score_spread":0.3274362468158283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}