{"id":"W3013797294","doi":"10.1007/s40257-020-00510-6","title":"Safety, Effectiveness, and Pharmacokinetics of Crisaborole in Infants Aged 3 to < 24 Months with Mild-to-Moderate Atopic Dermatitis: A Phase IV Open-Label Study (CrisADe CARE 1)","year":2020,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology","funders":"Pfizer","keywords":"Medicine; Atopic dermatitis; Pharmacokinetics; Open label; Pharmacotherapy; Dermatology; Anesthesia; Adverse effect; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001121209,0.0004175647,0.00101416,0.0001947368,0.0001683156,0.0003185199,0.0003033859,0.0004570385,0.0007612475],"category_scores_gemma":[0.0007937427,0.0001971125,0.0006380606,0.0001401539,0.0003295276,0.0003171304,0.000153612,0.0009596477,0.0001654222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000303041,"about_ca_system_score_gemma":0.0004467902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004306207,"about_ca_topic_score_gemma":0.001203032,"domain_scores_codex":[0.9996282,0.0002004715,0.00003054344,0.00004498266,0.00006026157,0.00003549318],"domain_scores_gemma":[0.9994957,0.0001321213,0.0001780535,0.00003322769,0.00004029118,0.0001205856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4494012,0.06176755,0.07037237,0.001937159,0.001576041,0.001278347,0.0009010074,0.001602121,0.1696302,0.0001856992,0.001570237,0.239778],"study_design_scores_gemma":[0.04918082,0.8031613,0.1332386,0.00005688035,0.000584421,0.0009669848,0.000148652,0.001008338,0.009382489,0.00005467157,0.002180452,0.00003641519],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985929,0.0008828992,0.00009311335,0.00002749429,0.000008285199,0.0001423752,0.00009987156,0.000008337187,0.0001446089],"genre_scores_gemma":[0.9971975,0.001186713,0.0006284355,0.0001335143,0.00004009787,0.0002082554,0.0002868978,0.00000449844,0.0003141211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001121209,"threshold_uncertainty_score":0.005929589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04448782415435957,"score_gpt":0.4222697355113028,"score_spread":0.3777819113569432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}