{"id":"W3013797294","doi":"10.1007/s40257-020-00510-6","title":"Safety, Effectiveness, and Pharmacokinetics of Crisaborole in Infants Aged 3 to < 24 Months with Mild-to-Moderate Atopic Dermatitis: A Phase IV Open-Label Study (CrisADe CARE 1)","year":2020,"lang":"en","type":"article","venue":"American Journal of Clinical Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lynde Centre for Dermatology","funders":"Pfizer","keywords":"Medicine; Atopic dermatitis; Pharmacokinetics; Open label; Pharmacotherapy; Dermatology; Anesthesia; Adverse effect; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003929416,0.0002819176,0.002439828,0.0002158763,0.00006660906,0.00002182255,0.0004092975,0.00009963001,0.00002098625],"category_scores_gemma":[0.001120915,0.0002253633,0.00009655189,0.0005924067,0.0004760243,0.0001546391,0.0002361605,0.0006432201,0.000007382345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000224832,"about_ca_system_score_gemma":0.0004012021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000461356,"about_ca_topic_score_gemma":0.00005543147,"domain_scores_codex":[0.9956608,0.001450077,0.001834554,0.0003966956,0.0003047796,0.000353083],"domain_scores_gemma":[0.9966294,0.00120233,0.0006918433,0.0002658718,0.0003546786,0.0008559466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02704958,0.003872084,0.9308612,0.000294449,0.0007161615,0.005186627,0.004227459,0.00008173118,0.0002120799,0.000009462469,0.003120755,0.02436836],"study_design_scores_gemma":[0.06212752,0.01024376,0.9178107,0.0005289738,0.0007528777,0.001651028,0.003929633,0.0002890981,0.0009364757,0.00003251349,0.001396985,0.0003004488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877786,0.001098427,0.0004694867,0.009140584,0.0001605002,0.001210203,0.00003111288,0.00001383537,0.00009727629],"genre_scores_gemma":[0.9868763,0.0003048516,0.001811264,0.01087677,0.00006335296,0.00002996826,0.000004684362,0.00003100274,0.000001805012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03507793,"threshold_uncertainty_score":0.9190049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04448782415435957,"score_gpt":0.4222697355113028,"score_spread":0.3777819113569432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}