{"id":"W3013818906","doi":"10.29173/hsi11","title":"Altered State of Mind: Direct Cellular Reprogramming as Potential Treatment Strategy for Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Reprogramming; Disease; Alzheimer's disease; Neuroscience; Medicine; Biology; Internal medicine; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002134123,0.0002163942,0.0001944629,0.0001835454,0.0002033566,0.0005039143,0.0003138423,0.0004199106,0.002527766],"category_scores_gemma":[0.0002301169,0.00006886117,0.0002844564,0.0001285599,0.000439019,0.0004254007,0.0003158859,0.0008664564,0.0003226644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200323,"about_ca_system_score_gemma":0.0002268945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002291927,"about_ca_topic_score_gemma":0.0004545214,"domain_scores_codex":[0.9999403,0.00001262129,0.000004124027,0.00001599816,0.00001370431,0.00001316166],"domain_scores_gemma":[0.999956,0.00001498442,0.000007805192,0.000008561591,0.000006104262,0.000006645213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007878365,0.0003999312,0.001471963,0.0005765419,0.0000929093,0.0006442053,0.0004122358,0.0005069742,0.7289811,0.03459193,0.002697221,0.2288372],"study_design_scores_gemma":[0.0003093106,0.003118497,0.009749627,0.0002363799,0.0005051301,0.004949574,0.0009182733,0.002199186,0.8212473,0.04855957,0.1081479,0.00005918839],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8272932,0.06097273,0.05149252,0.009551867,0.002108319,0.0001816728,0.0007056477,0.0004773481,0.04721682],"genre_scores_gemma":[0.9716799,0.01590499,0.005733053,0.0008472131,0.0001276724,0.00007541326,0.0001530464,0.00002324988,0.005455508],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002527766,"threshold_uncertainty_score":0.00845623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07759612379344062,"score_gpt":0.3903487809670149,"score_spread":0.3127526571735743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}