{"id":"W3013818906","doi":"10.29173/hsi11","title":"Altered State of Mind: Direct Cellular Reprogramming as Potential Treatment Strategy for Alzheimer’s Disease","year":2019,"lang":"en","type":"article","venue":"Health Science Inquiry","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Reprogramming; Disease; Alzheimer's disease; Neuroscience; Medicine; Biology; Internal medicine; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008812158,0.0001619888,0.0002260227,0.0001147953,0.0001901519,0.00004534022,0.0003601598,0.00004231237,0.00001790449],"category_scores_gemma":[0.0000278903,0.0001416734,0.000119,0.0002123769,0.0004292251,0.00001486151,0.0001358067,0.00004913456,0.00002889557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006597131,"about_ca_system_score_gemma":0.001694369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001555658,"about_ca_topic_score_gemma":0.000008943571,"domain_scores_codex":[0.9975928,0.00005296019,0.0003528387,0.0007694308,0.0004347675,0.0007971895],"domain_scores_gemma":[0.9985325,0.0000132904,0.0001865332,0.0006508547,0.0001642249,0.0004525802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007171037,0.0004028288,0.00368061,0.0001997476,0.00005951708,0.00001141593,0.0003395382,0.002228009,0.8364064,0.00002037209,0.00025102,0.1556834],"study_design_scores_gemma":[0.001679074,0.005436311,0.007292751,0.00006540181,0.00003433732,0.000008406125,0.0003671667,0.003943959,0.9668396,0.00009893729,0.01384299,0.0003910438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950723,0.002336606,0.0003803169,0.0001997529,0.00043179,0.001364077,0.00004396564,0.000009051345,0.0001621373],"genre_scores_gemma":[0.9980219,0.0002599534,0.0006331833,0.00008604198,0.0001502225,0.00007351291,0.00009478127,0.00001801365,0.0006624174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1552924,"threshold_uncertainty_score":0.5777274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07759612379344062,"score_gpt":0.3903487809670149,"score_spread":0.3127526571735743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}