{"id":"W3013826160","doi":"10.1101/2020.03.24.006379","title":"Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancer","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Lapatinib; Cancer research; Trastuzumab; Breast cancer; Pertuzumab; Gene silencing; Cancer; Medicine; Downregulation and upregulation; Receptor tyrosine kinase; Tyrosine kinase; Biology; Internal medicine; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000120922,0.0001156544,0.0001707005,0.0001690723,0.0001090708,0.0001855781,0.00007706765,0.0001621821,0.001249185],"category_scores_gemma":[0.0001220083,0.0000866409,0.0001935763,0.000137289,0.00009497474,0.000149203,0.0001372184,0.0003495742,0.0001899699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017315,"about_ca_system_score_gemma":0.00009334546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002731117,"about_ca_topic_score_gemma":0.0005378777,"domain_scores_codex":[0.9999017,0.00001409167,0.000007488512,0.00001794651,0.00003544132,0.00002333057],"domain_scores_gemma":[0.9999299,0.000009555924,0.00002509836,0.000006241127,0.00001742054,0.00001177549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347439,0.00004676834,0.004082403,0.00005914797,0.00001883647,0.0001367366,0.00002300203,0.0001357603,0.9911942,0.0001134642,0.0001413004,0.003913753],"study_design_scores_gemma":[0.00002408451,0.0006331131,0.1014458,0.00001488319,0.00006717473,0.001522119,0.0001175679,0.002757345,0.8869417,0.00018179,0.006284624,0.000009745369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929595,0.003379457,0.001762246,0.000140887,0.00003588463,0.00002301488,0.0003154944,0.00005504669,0.001328503],"genre_scores_gemma":[0.9976764,0.0005831324,0.0002718926,0.0000716223,0.000005975397,0.00001290619,0.0002099729,0.000003111991,0.001164938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001249185,"threshold_uncertainty_score":0.004178941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149724952856653,"score_gpt":0.285974408011228,"score_spread":0.2644771584826615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}