{"id":"W3013840919","doi":"10.3389/fgene.2020.00224","title":"Impact of ex vivo Sample Handling on DNA Methylation Profiles in Human Cord Blood and Neonatal Dried Blood Spots","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; Kids Brain Health Network; Fondation Brain Canada","keywords":"Ex vivo; Cord blood; Spots; DNA methylation; Andrology; DNA; Umbilical cord; Medicine; Biology; In vivo; Pathology; Immunology; Molecular biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753834,0.0001789179,0.0002493256,0.0001168067,0.00003615885,0.00001967721,0.0001352587,0.0001875532,0.00000707224],"category_scores_gemma":[0.0001465955,0.0001888024,0.0000710619,0.000174395,0.00007080424,0.000004157207,0.00007748231,0.0001149326,2.014875e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001325965,"about_ca_system_score_gemma":0.00005514222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004680987,"about_ca_topic_score_gemma":0.00003386648,"domain_scores_codex":[0.9988116,0.00008294947,0.0003599181,0.0003718701,0.0001554783,0.0002181776],"domain_scores_gemma":[0.9994925,0.0000222423,0.0001395193,0.0002031759,0.00005032846,0.00009227561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001352803,0.00007814047,0.3445725,0.00002829428,0.00005417812,0.000002889468,0.0002379396,0.00192063,0.6466247,0.000009800169,0.00003586727,0.006299768],"study_design_scores_gemma":[0.001542073,0.001442662,0.1085253,0.00002375542,0.00004324863,6.314276e-7,0.00007877118,0.001204972,0.8862606,0.0004498862,0.000217964,0.0002100866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896693,0.003607585,0.006158326,0.00002604882,0.00008867899,0.000290811,0.00007080754,0.000005639358,0.00008281132],"genre_scores_gemma":[0.9868284,0.0008867568,0.01195645,0.00002491718,0.0001084917,0.000007799298,0.0001490983,0.00002665875,0.00001144466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2396359,"threshold_uncertainty_score":0.7699137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155555763564902,"score_gpt":0.274475462358729,"score_spread":0.2589198860022388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}