{"id":"W3013840919","doi":"10.3389/fgene.2020.00224","title":"Impact of ex vivo Sample Handling on DNA Methylation Profiles in Human Cord Blood and Neonatal Dried Blood Spots","year":2020,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; Kids Brain Health Network; Fondation Brain Canada","keywords":"Ex vivo; Cord blood; Spots; DNA methylation; Andrology; DNA; Umbilical cord; Medicine; Biology; In vivo; Pathology; Immunology; Molecular biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007932902,0.000275966,0.0002745062,0.0002220735,0.0002588538,0.0005022706,0.0002603636,0.0002504701,0.001526061],"category_scores_gemma":[0.001347224,0.0001598237,0.0002161336,0.0003394699,0.0002999682,0.0001560069,0.0002473418,0.0003547367,0.0003400234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001854247,"about_ca_system_score_gemma":0.0002386177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355262,"about_ca_topic_score_gemma":0.00189464,"domain_scores_codex":[0.9993735,0.0001975812,0.00005861654,0.0001739529,0.0001576093,0.00003874693],"domain_scores_gemma":[0.9995111,0.0001515957,0.0001034291,0.00007945832,0.0001262811,0.00002809743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006740383,0.00003444431,0.005236198,0.00009245735,0.00003348954,0.0001009808,0.000188947,0.0001432704,0.9873191,0.00004196581,0.00009372992,0.006041337],"study_design_scores_gemma":[0.00001013601,0.0005643883,0.04792321,0.00002001363,0.00009399691,0.0005075782,0.0001623118,0.0007565159,0.947179,0.00009915383,0.00266479,0.0000189712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831767,0.002880896,0.01153082,0.0001460465,0.00007260933,0.00007019346,0.001045901,0.00008503265,0.0009918222],"genre_scores_gemma":[0.9762343,0.001657263,0.01673063,0.0001952549,0.00003331218,0.0001506548,0.002337642,0.00009337036,0.002567717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526061,"threshold_uncertainty_score":0.005105197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0155555763564902,"score_gpt":0.274475462358729,"score_spread":0.2589198860022388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}