{"id":"W3013897686","doi":"10.1186/s13075-020-2138-x","title":"Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells","year":2020,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Yang-Ming University; National Taiwan University; Academia Sinica; Ministry of Science and Technology; Bristol-Myers Squibb","keywords":"CD80; CD86; Cytotoxic T cell; CTLA-4; Immunology; Antigen; Cytokine; Antigen-presenting cell; Molecular biology; T cell; B cell; Biology; Antibody; CD40; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278368,0.0002566678,0.0001836873,0.0001490131,0.00007797239,0.0001206622,0.0001044253,0.0001579681,0.0009008993],"category_scores_gemma":[0.0001128729,0.0000700169,0.0002020402,0.00009166464,0.000144124,0.00005389152,0.0001140927,0.0002965604,0.0002641439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009078543,"about_ca_system_score_gemma":0.0001474804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002534723,"about_ca_topic_score_gemma":0.0002421663,"domain_scores_codex":[0.9999125,0.00001667675,0.000009363822,0.0000127723,0.00001985721,0.00002866868],"domain_scores_gemma":[0.999925,0.00001630387,0.00001880291,0.00001023538,0.00001057058,0.00001898681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002834038,0.0001329459,0.0004402992,0.00003363964,0.000005112728,0.00004111843,0.00001290411,0.00003524826,0.9975496,0.000007285733,0.000021479,0.00143699],"study_design_scores_gemma":[0.00009104638,0.004026361,0.01044418,0.000009794589,0.00003641884,0.0004603027,0.00003431196,0.0005612845,0.9833193,0.00001738239,0.0009967309,0.000002725894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989221,0.0004828942,0.0002436696,0.00001840128,0.000008440127,0.000008856015,0.00002970732,0.00001969126,0.0002662372],"genre_scores_gemma":[0.9985026,0.0003138551,0.0003463331,0.00002717654,0.00001081305,0.00001786072,0.0001699858,0.000004611875,0.0006067377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009008993,"threshold_uncertainty_score":0.00301379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03985474587890341,"score_gpt":0.2935136333510762,"score_spread":0.2536588874721727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}