{"id":"W3013906244","doi":"10.3389/fonc.2020.00448","title":"CRISPR/Cas9-Mediated Foxp1 Silencing Restores Immune Surveillance in an Immunocompetent A20 Lymphoma Model","year":2020,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children","funders":"Medical Research Council; Wellcome Trust; Bloodwise; Blood Cancer UK; University of Oxford; Cancer Research UK","keywords":"Cancer research; Immune system; Biology; Diffuse large B-cell lymphoma; Lymphoma; Immunology; T cell; Major histocompatibility complex","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002369504,0.0005069516,0.0002949627,0.0005656363,0.0001905517,0.0004261041,0.0003292522,0.0005767469,0.002346657],"category_scores_gemma":[0.0001552858,0.0001740502,0.0003291458,0.0001585063,0.0003120432,0.0002583045,0.0002294546,0.0009385617,0.0007075311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003536051,"about_ca_system_score_gemma":0.0002008069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110431,"about_ca_topic_score_gemma":0.00112652,"domain_scores_codex":[0.9997612,0.00002468524,0.00002626543,0.00006985822,0.00006539495,0.00005266341],"domain_scores_gemma":[0.9997452,0.00002989546,0.00007261343,0.00002562489,0.00001900073,0.0001076994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001419024,0.00009314941,0.0001156077,0.0000253604,0.000007508175,0.0001195569,0.00002458933,0.0001159876,0.9979437,0.0002036428,0.0001221847,0.001086784],"study_design_scores_gemma":[0.00009759721,0.001083144,0.00274883,0.00001793576,0.00003397972,0.0007306806,0.00006441696,0.004246386,0.9841431,0.0001868209,0.006631689,0.00001529687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847435,0.001002731,0.008351624,0.0002288682,0.0001169148,0.0001200038,0.001402645,0.0007061634,0.003327614],"genre_scores_gemma":[0.9884292,0.00052359,0.002951792,0.0001217124,0.00001327779,0.000110962,0.001116166,0.0001025421,0.006630609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002346657,"threshold_uncertainty_score":0.007850349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03935570422577517,"score_gpt":0.3313108579041001,"score_spread":0.291955153678325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}