{"id":"W3013922258","doi":"10.1042/cs20191160","title":"Self DNA perpetuates IPF lung fibroblast senescence in a cGAS-dependent manner","year":2020,"lang":"en","type":"article","venue":"Clinical Science","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Providence Health Care Research Institute","funders":"National Health and Medical Research Council; Lung Foundation Australia; Rijksuniversiteit Groningen; European Commission","keywords":"Senescence; Idiopathic pulmonary fibrosis; DNA damage; Gene knockdown; Cancer research; Biology; Endogeny; Cell biology; Molecular biology; Cell culture; Lung; Medicine; Internal medicine; Endocrinology; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007741278,0.0001569263,0.000344267,0.00006242484,0.0001205139,0.00005801212,0.0004126035,0.00009283365,0.0001850321],"category_scores_gemma":[0.0009068542,0.0001251349,0.0001713769,0.0006501228,0.000588119,0.0002458942,0.0002622778,0.000359072,0.0002198084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001018947,"about_ca_system_score_gemma":0.0004175954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002697007,"about_ca_topic_score_gemma":0.000003792434,"domain_scores_codex":[0.9976107,0.00006578933,0.0005619273,0.0007247551,0.0005687341,0.0004680402],"domain_scores_gemma":[0.9986396,0.0001351111,0.00008605887,0.0002863922,0.0001177967,0.0007349962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01144192,0.00475114,0.835921,0.002256792,0.000110292,0.004026783,0.004045092,0.000156975,0.1107851,0.00730233,0.008337891,0.01086461],"study_design_scores_gemma":[0.006712189,0.01645443,0.6098917,0.003578927,0.000346034,0.0002662547,0.001658581,0.341965,0.006041584,0.0006571269,0.01072893,0.001699287],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822646,0.0002347128,0.0001879336,0.01076842,0.0003982081,0.000459185,0.00002119745,0.0001437962,0.005521939],"genre_scores_gemma":[0.9954202,0.00009648721,0.0007848533,0.003060566,0.0004457608,0.000010046,0.000004093389,0.00001193559,0.0001661001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.341808,"threshold_uncertainty_score":0.5102853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02951480697079788,"score_gpt":0.3393217478938285,"score_spread":0.3098069409230306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}