{"id":"W3013942217","doi":"10.1002/glia.23831","title":"The inhibition of Kir2.1 potassium channels depolarizes spinal microglial cells, reduces their proliferation, and attenuates neuropathic pain","year":2020,"lang":"en","type":"article","venue":"Glia","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institute of Neurological Disorders and Stroke; SCIEX; Foundation for the National Institutes of Health","keywords":"SNi; Microglia; Neuropathic pain; Nerve injury; Neuroscience; Electrophysiology; Hyperpolarization (physics); Pharmacology; Biology; Potassium channel; Nerve growth factor; Medicine; Cell biology; Anesthesia; Immunology; Internal medicine; Endocrinology; Chemistry; Receptor; Inflammation; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004713416,0.0001196235,0.0001631587,0.00002053732,0.0001517284,0.00003450018,0.00003762487,0.00005154073,0.000004709016],"category_scores_gemma":[0.0001909588,0.00007385668,0.00004374631,0.0000769614,0.00006564357,0.00004764334,0.00002839212,0.000108281,0.0000063013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008913611,"about_ca_system_score_gemma":0.00004161744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001189783,"about_ca_topic_score_gemma":0.000002464014,"domain_scores_codex":[0.9991292,0.0002110052,0.0001947285,0.0001876311,0.0001280486,0.0001493539],"domain_scores_gemma":[0.999593,0.00005872645,0.00009038336,0.00009656345,0.00006884557,0.00009245286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002631516,0.00007193672,0.001561164,0.00008109001,0.00004213452,0.00004645369,0.000568629,8.966809e-7,0.9863185,0.000101915,0.0003013727,0.01064279],"study_design_scores_gemma":[0.000808497,0.001044744,0.001463962,0.00009173026,0.00006163192,0.00002542103,0.0002787318,0.001309979,0.9937787,0.0004298767,0.0006254303,0.00008127518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903212,0.0009073097,0.0006238538,0.007542292,0.0001472814,0.0003718647,0.00002318767,0.00003359303,0.00002939102],"genre_scores_gemma":[0.9982977,0.0001248069,0.0002858206,0.0008912757,0.0003008074,0.00001791088,0.00001818551,0.00001337797,0.00005013816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01056152,"threshold_uncertainty_score":0.3011788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01787924797499639,"score_gpt":0.2308873458536145,"score_spread":0.2130080978786181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}