{"id":"W3013988004","doi":"10.1126/science.aba4624","title":"Antisense oligonucleotides for neurodegeneration","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Neurodegeneration; Oligonucleotide; Huntington's disease; Disease; Biology; Computational biology; Medicine; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116958,0.0001146519,0.00009382462,0.00005988799,0.0004333846,0.0001755697,0.0004707364,0.00001268827,0.0000249209],"category_scores_gemma":[0.003073998,0.0001072503,0.0000480764,0.0007519184,0.0004906349,0.0003164093,0.00009774456,0.00004679675,0.00009456046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000114032,"about_ca_system_score_gemma":0.0001554486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.884546e-7,"about_ca_topic_score_gemma":4.889082e-7,"domain_scores_codex":[0.998349,0.000049747,0.0001478756,0.0007418739,0.0003809588,0.0003305628],"domain_scores_gemma":[0.9992745,0.00009849012,0.00005513879,0.0002154184,0.00009563989,0.000260822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001263556,0.00001573817,0.0001379956,0.000006205513,1.717764e-7,0.000002718381,0.0001091124,0.0008101102,0.9945425,0.002809458,0.0004269287,0.001126462],"study_design_scores_gemma":[0.0001697965,0.000126188,0.001719524,0.000001695832,0.000003737117,0.000003139035,0.00001363032,0.01633979,0.9791656,0.0002624574,0.002074652,0.0001197937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912258,0.00001664176,0.004456208,0.002904767,0.0003373559,0.0003746854,0.00003305562,0.0001112893,0.0005401946],"genre_scores_gemma":[0.9894077,0.000009737631,0.001646855,0.008691452,0.0001472438,0.00002371685,7.788701e-7,0.00001420322,0.00005826745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01552968,"threshold_uncertainty_score":0.4373541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07881021965645718,"score_gpt":0.3010076567441937,"score_spread":0.2221974370877365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}