{"id":"W3013988004","doi":"10.1126/science.aba4624","title":"Antisense oligonucleotides for neurodegeneration","year":2020,"lang":"en","type":"article","venue":"Science","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"","keywords":"Neurodegeneration; Oligonucleotide; Huntington's disease; Disease; Biology; Computational biology; Medicine; Genetics; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000430703,0.0005448369,0.0003809037,0.0002914195,0.000271675,0.0003328837,0.0002947586,0.0007304845,0.003730634],"category_scores_gemma":[0.0002961047,0.0001552224,0.0002801367,0.0001440976,0.0002982597,0.0002921038,0.0002268698,0.001077956,0.0006949109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266032,"about_ca_system_score_gemma":0.000348335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005942607,"about_ca_topic_score_gemma":0.001317038,"domain_scores_codex":[0.9999028,0.00002080008,0.00001046759,0.00002337073,0.00001986545,0.00002253273],"domain_scores_gemma":[0.9999119,0.00003527366,0.00001428634,0.00000677552,0.00001368561,0.00001802989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001054146,0.0004132846,0.0004554855,0.000490425,0.00009297143,0.0004846125,0.00009844974,0.0005969604,0.8832001,0.01293842,0.005723827,0.09445134],"study_design_scores_gemma":[0.002139432,0.009051167,0.003794452,0.0002281886,0.0004102571,0.003195543,0.000135163,0.001955484,0.7118257,0.01150782,0.2556569,0.00009993179],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6691371,0.1783712,0.07323989,0.01272225,0.007242852,0.0008669707,0.001942132,0.001804736,0.0546729],"genre_scores_gemma":[0.8483355,0.07532477,0.03192687,0.00510198,0.0009315479,0.0009627698,0.001703854,0.0002007662,0.03551206],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003730634,"threshold_uncertainty_score":0.0124802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07881021965645718,"score_gpt":0.3010076567441937,"score_spread":0.2221974370877365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}