{"id":"W3014011642","doi":"10.1158/1538-7445.sabcs19-p1-19-46","title":"Abstract P1-19-46: A phase Ib dose escalation study evaluating the mutant selective PI3K-alpha inhibitor GDC-0077 (G) in combination with letrozole (L) with and without palbociclib (P) in patients with <i>PIK3CA</i>-mutant HR+/HER2- breast cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Palbociclib; Medicine; Letrozole; Breast cancer; Pharmacodynamics; Cancer; Pharmacokinetics; Pharmacology; Metastatic breast cancer; Combination therapy; PI3K/AKT/mTOR pathway; Internal medicine; Chemistry; Signal transduction; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008947146,0.00157549,0.001583682,0.000588041,0.0003915286,0.001236911,0.00103364,0.001006574,0.00429656],"category_scores_gemma":[0.0005891285,0.0005852836,0.001164951,0.0005249975,0.001076554,0.0008742744,0.000405158,0.004076893,0.001280964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001082924,"about_ca_system_score_gemma":0.00193375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276923,"about_ca_topic_score_gemma":0.002846067,"domain_scores_codex":[0.9995996,0.0001557312,0.00002035572,0.00007843148,0.0000528502,0.00009294881],"domain_scores_gemma":[0.999549,0.00004976534,0.00007180376,0.00003868317,0.00002702453,0.0002637026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5838119,0.1255053,0.006232759,0.0009586422,0.001993969,0.0005845068,0.0003833139,0.005065376,0.1251077,0.000646361,0.007131304,0.1425789],"study_design_scores_gemma":[0.4329401,0.5410416,0.008674754,0.00003686301,0.000542236,0.0004631343,0.0000727214,0.001428304,0.01045837,0.0002417545,0.004058312,0.00004193342],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890596,0.001703492,0.0008966958,0.0005181075,0.0001069459,0.002631307,0.00175801,0.0001906196,0.003135201],"genre_scores_gemma":[0.9884543,0.001551159,0.0018026,0.0006421522,0.0001065894,0.001761441,0.002679223,0.00005031284,0.002952288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00429656,"threshold_uncertainty_score":0.01437348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05716388963729137,"score_gpt":0.4168440748850469,"score_spread":0.3596801852477556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}