{"id":"W3014011642","doi":"10.1158/1538-7445.sabcs19-p1-19-46","title":"Abstract P1-19-46: A phase Ib dose escalation study evaluating the mutant selective PI3K-alpha inhibitor GDC-0077 (G) in combination with letrozole (L) with and without palbociclib (P) in patients with <i>PIK3CA</i>-mutant HR+/HER2- breast cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Palbociclib; Medicine; Letrozole; Breast cancer; Pharmacodynamics; Cancer; Pharmacokinetics; Pharmacology; Metastatic breast cancer; Combination therapy; PI3K/AKT/mTOR pathway; Internal medicine; Chemistry; Signal transduction; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001136463,0.000424188,0.0006248819,0.0003238905,0.0003048115,0.0001067981,0.0002155089,0.00009875916,0.0001169677],"category_scores_gemma":[0.0001165062,0.0002609482,0.0000287747,0.002245168,0.0004882148,0.0005226422,0.00009690307,0.001369254,0.00000279982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001505574,"about_ca_system_score_gemma":0.001376049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003619371,"about_ca_topic_score_gemma":0.007315268,"domain_scores_codex":[0.9952143,0.0004341047,0.0005107512,0.000966076,0.002045343,0.0008293855],"domain_scores_gemma":[0.9977713,0.0002196662,0.0002666242,0.000384977,0.001017916,0.000339467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05386927,0.00203448,0.8646621,0.0002208686,0.0002431868,0.00006729672,0.013827,0.001201972,0.01045533,0.000007525482,0.00001795046,0.05339304],"study_design_scores_gemma":[0.05977714,0.01145768,0.9162315,0.001275757,0.000110351,0.00002165354,0.006495438,0.001702289,0.002439267,0.00003153614,0.00004561733,0.0004118035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910077,0.000458918,0.00006608725,0.002936707,0.00003614783,0.005284391,0.00008962051,0.00005849093,0.00006193361],"genre_scores_gemma":[0.9975563,0.00004955587,0.0001052505,0.0003050473,0.0001958606,0.00162178,0.00002899106,0.0001145115,0.00002264925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05298124,"threshold_uncertainty_score":0.9999843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05716388963729137,"score_gpt":0.4168440748850469,"score_spread":0.3596801852477556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}