{"id":"W3014053429","doi":"10.1038/s41598-020-61683-y","title":"Mucosal delivery of CpG-ODN mimicking bacterial DNA via the intrapulmonary route induces systemic antimicrobial immune responses in neonatal chicks","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; University of Saskatchewan","funders":"Western Economic Diversification Canada; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Chicken Farmers of Saskatchewan; Alberta Livestock and Meat Agency; Government of Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Poultry Research Council","keywords":"CpG Oligodeoxynucleotide; Cytokine; CpG site; Immune system; Immunology; Tumor necrosis factor alpha; Lipopolysaccharide; Immunity; Interleukin 10; Innate immune system; Biology; Lung; Medicine; Andrology; Gene expression; Internal medicine; Gene; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588593,0.0002883202,0.0003184109,0.0001421871,0.00008022581,0.0001611884,0.0001243441,0.0002744134,0.0006991859],"category_scores_gemma":[0.0001727983,0.0001368381,0.0001699935,0.00004783641,0.0002751013,0.0001690072,0.0001491498,0.0007078258,0.0001973014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732199,"about_ca_system_score_gemma":0.0001571549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007206848,"about_ca_topic_score_gemma":0.001114739,"domain_scores_codex":[0.9998983,0.00001423243,0.000009332932,0.00002982502,0.00002258499,0.00002573467],"domain_scores_gemma":[0.9998468,0.0000259127,0.00004487166,0.00001231285,0.00002421189,0.00004590738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001849837,0.0000248185,0.0001662433,0.00003256742,0.000001641609,0.00002096143,0.00001720607,0.00001970745,0.9990401,0.000005948975,0.000007652468,0.0004780914],"study_design_scores_gemma":[0.00002279562,0.005263722,0.01493128,0.00001804748,0.00001955041,0.0001659744,0.0001538063,0.0005025206,0.978239,0.00001772618,0.0006587441,0.000006841935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980105,0.000503525,0.001034666,0.00003611828,0.00002324706,0.00002522756,0.0001029093,0.0000216084,0.0002422318],"genre_scores_gemma":[0.9959961,0.0004647233,0.001745374,0.0000740734,0.000008806677,0.00004313183,0.0001396003,0.000009001235,0.001519204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007206848,"threshold_uncertainty_score":0.002339005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182373427448869,"score_gpt":0.2134869171351848,"score_spread":0.2016631828606961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}