{"id":"W3014096086","doi":"10.1111/all.14299","title":"Epinephrine drives human M2a allergic macrophages to a regulatory phenotype reducing mast cell degranulation in vitro","year":2020,"lang":"en","type":"letter","venue":"Allergy","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; Austrian Science Fund; Academy of Medical Sciences; Cancer Research UK","keywords":"Degranulation; Epinephrine; Mast cell; In vitro; Immunology; Phenotype; Allergy; Immunoglobulin E; Medicine; Chemistry; Internal medicine; Antibody; Gene; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00009631228,0.0005638602,0.0007962136,0.0004077994,0.0002095023,0.000033714,0.0004985403,0.0008818452,0.002812738],"category_scores_gemma":[0.00001858812,0.0005867413,0.0001911794,0.000258167,0.0001430792,0.00005973398,0.0002506631,0.001485004,0.0008225231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001166273,"about_ca_system_score_gemma":0.00006954334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006720581,"about_ca_topic_score_gemma":0.0002111402,"domain_scores_codex":[0.9973188,0.0002498829,0.0006763306,0.0009449463,0.0001002717,0.0007097599],"domain_scores_gemma":[0.9989104,0.00007570005,0.0002756616,0.0006209182,0.00006469385,0.00005264797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001210529,0.00005097871,0.000005748203,0.0001221901,0.0001132641,0.0002538051,0.0004714455,0.00005649617,0.502867,0.00003591731,0.4950408,0.0008613084],"study_design_scores_gemma":[0.001204818,0.0001704614,0.0009469048,0.0001068481,0.00003083561,0.00001380416,0.00003310598,0.000008911637,0.03185851,0.00007800728,0.9649472,0.0006006417],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2839594,0.0283497,0.0002649571,0.6239989,0.006716919,0.003299102,0.0006695376,0.0009952412,0.05174625],"genre_scores_gemma":[0.5547329,0.000390953,0.0010667,0.3175419,0.003178715,0.0001869745,0.01372334,0.0003816751,0.1087969],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4710084,"threshold_uncertainty_score":0.9999555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085061238301464,"score_gpt":0.2122141137097063,"score_spread":0.2013635013266916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}