{"id":"W3014096086","doi":"10.1111/all.14299","title":"Epinephrine drives human M2a allergic macrophages to a regulatory phenotype reducing mast cell degranulation in vitro","year":2020,"lang":"en","type":"letter","venue":"Allergy","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Medical Research Council; Austrian Science Fund; Academy of Medical Sciences; Cancer Research UK","keywords":"Degranulation; Epinephrine; Mast cell; In vitro; Immunology; Phenotype; Allergy; Immunoglobulin E; Medicine; Chemistry; Internal medicine; Antibody; Gene; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009871301,0.0003278608,0.0003520895,0.0001790438,0.0002675693,0.0004621122,0.000505385,0.0007328867,0.004655906],"category_scores_gemma":[0.000853577,0.0001811655,0.0004049887,0.0001750326,0.0002356677,0.0002731088,0.0003137044,0.001204483,0.002127505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263975,"about_ca_system_score_gemma":0.000209548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002156936,"about_ca_topic_score_gemma":0.000369264,"domain_scores_codex":[0.9992092,0.0002196318,0.00009674871,0.0001272756,0.0002207778,0.000126436],"domain_scores_gemma":[0.9993758,0.0002049534,0.00004850427,0.00005955928,0.0002480636,0.00006322319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002986131,0.0005038867,0.002743942,0.00151995,0.00005475798,0.001262113,0.0002679866,0.0001620309,0.9206569,0.0006492989,0.03334222,0.03585081],"study_design_scores_gemma":[0.0003678773,0.002576356,0.01533281,0.0003155709,0.0002159521,0.001878686,0.0003349793,0.001478234,0.6774511,0.0005149901,0.2994882,0.0000452108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7292526,0.1290673,0.02238545,0.03370636,0.05885737,0.0008488664,0.005996299,0.0007038819,0.01918183],"genre_scores_gemma":[0.8922957,0.03533977,0.01070775,0.01216218,0.01359002,0.0005669799,0.003836396,0.0002091974,0.03129201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004655906,"threshold_uncertainty_score":0.01557553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085061238301464,"score_gpt":0.2122141137097063,"score_spread":0.2013635013266916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}