{"id":"W3014110401","doi":"10.1016/j.envres.2020.109483","title":"Ozone increases plasma kynurenine-tryptophan ratio and impacts hippocampal serotonin receptor and neurotrophic factor expression: Role of stress hormones","year":2020,"lang":"en","type":"article","venue":"Environmental Research","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; University of Ottawa","funders":"Health Canada","keywords":"Endocrinology; Internal medicine; Kynurenine; Neurotrophic factors; Aryl hydrocarbon receptor; Glucocorticoid; Metyrapone; Brain-derived neurotrophic factor; Glucocorticoid receptor; Tryptophan hydroxylase; Kynurenine pathway; Chemistry; Serotonin; Receptor; Biology; Serotonergic; Medicine; Tryptophan; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004813265,0.0002005053,0.0002350422,0.00009380792,0.0002419837,0.000086831,0.0002534015,0.00008461496,0.0005230531],"category_scores_gemma":[0.0005505136,0.0001734208,0.00003997763,0.0001720396,0.0005578777,0.0002339285,0.0005440196,0.0003651922,0.00003283342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002898884,"about_ca_system_score_gemma":0.00003314238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005011477,"about_ca_topic_score_gemma":0.000002914423,"domain_scores_codex":[0.997442,0.0004828541,0.0002479725,0.0005788008,0.0008190142,0.0004293317],"domain_scores_gemma":[0.9986687,0.000528142,0.0000816105,0.0002328828,0.000007587233,0.000481029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001124972,0.0001325879,0.0272468,0.00003022174,0.000004140066,0.00003223744,0.0005632341,0.000005811981,0.9608561,0.00002043516,0.00003147644,0.009951915],"study_design_scores_gemma":[0.0007028899,0.0009694694,0.09918442,0.00003900347,0.000003238647,0.0000153505,0.0006436789,0.0007591703,0.8972321,0.0000395535,0.000264952,0.0001461739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978504,0.0009407348,0.000004535982,0.0002786088,0.00001865785,0.0005117243,0.0003216242,0.0000228033,0.00005095128],"genre_scores_gemma":[0.995828,0.003804725,0.00005011576,0.00005840119,0.00008019155,0.00005809759,0.00000814214,0.00002998854,0.00008234408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07193762,"threshold_uncertainty_score":0.7071896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04434163387847233,"score_gpt":0.2975009081594681,"score_spread":0.2531592742809957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}