{"id":"W3014201940","doi":"10.1039/d0md00033g","title":"Unveiling the active isomer of cycloalanopine, a cyclic opine from <i>Lactobacillus rhamnosus</i> LS8, through synthesis and analog production","year":2020,"lang":"en","type":"article","venue":"RSC Medicinal Chemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lactobacillus rhamnosus; Production (economics); Lactobacillus; Chemistry; Stereochemistry; Food science; Economics; Fermentation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000075492,0.0002007682,0.0003895018,0.00001037462,0.0001401997,0.000007482611,0.0001708645,0.0001740561,0.00052942],"category_scores_gemma":[0.000354318,0.000140042,0.00007759403,0.0001189416,0.0005753014,0.00009435863,0.00008670805,0.0003706572,0.00002042584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002054724,"about_ca_system_score_gemma":0.00005057154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003440499,"about_ca_topic_score_gemma":0.000005643347,"domain_scores_codex":[0.9990323,0.00005543689,0.0002727247,0.0003550808,0.0000597265,0.0002246977],"domain_scores_gemma":[0.9992827,0.0002324325,0.0001973808,0.0002062092,0.00005008965,0.00003121157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002698611,0.00003995973,0.0004690237,0.000127199,0.0002266824,0.000003979524,0.00129876,0.000004862356,0.99145,0.00001400103,0.004159027,0.001936613],"study_design_scores_gemma":[0.0004072077,0.0000516454,0.0009879976,0.0001668239,0.0001482536,0.00004871164,0.002975035,0.000004672074,0.9878027,0.00008503407,0.007171666,0.0001502428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879064,0.003312567,0.0001017179,0.006167322,0.0001923807,0.0001342285,0.0001370639,0.00004195356,0.002006365],"genre_scores_gemma":[0.9978277,0.0007073784,0.00006570919,0.0005850988,0.000343144,0.00001020533,0.00009312514,0.00001481158,0.0003528219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009921305,"threshold_uncertainty_score":0.5796778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471705293310807,"score_gpt":0.2178394693814779,"score_spread":0.2031224164483698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}