{"id":"W3014236860","doi":"10.1002/glia.23833","title":"HIV‐1 infection and latency‐reversing agents bryostatin‐1 and JQ1 disrupt amyloid beta homeostasis in human astrocytes","year":2020,"lang":"en","type":"article","venue":"Glia","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Saint-François d'Assise; Centre hospitalier universitaire de Québec; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Biology; Reversing; Latency (audio); Homeostasis; Bryostatin 1; Human immunodeficiency virus (HIV); Glioblastoma; Virology; Neuroscience; Immunology; Cell biology; Cancer research; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380436,0.0002255036,0.000301265,0.0001413656,0.0003576374,0.00005984002,0.00009198496,0.0001688133,0.00004876978],"category_scores_gemma":[0.0002225146,0.0002106123,0.00005140364,0.0002136191,0.000205337,0.0001810943,0.000162357,0.0003530635,0.0003444937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005411918,"about_ca_system_score_gemma":0.00003033545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004105135,"about_ca_topic_score_gemma":0.0002344723,"domain_scores_codex":[0.9985346,0.0001965821,0.0002372074,0.0004338072,0.00006250924,0.0005352812],"domain_scores_gemma":[0.9993709,0.0002473324,0.00008086198,0.0001429752,0.00003658957,0.000121297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003378179,0.0002487443,0.8904307,0.0001398112,0.0003768032,0.0001325738,0.006044777,0.000007442887,0.07363859,0.0001010109,0.017295,0.01155081],"study_design_scores_gemma":[0.00398472,0.0008277207,0.898787,0.00007361756,0.00008300081,0.00005130145,0.001349466,0.00001654724,0.04750156,0.00006733587,0.04717339,0.00008434858],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948034,0.003274268,0.00004434498,0.0001881285,0.00008607013,0.0003204925,0.0001921026,0.00006423699,0.001026986],"genre_scores_gemma":[0.9979077,0.0006138243,0.00009130614,0.0001067338,0.0000285993,0.00002140708,0.0003770012,0.00001964283,0.000833781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0298784,"threshold_uncertainty_score":0.8588521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02153705311368479,"score_gpt":0.2655028970735288,"score_spread":0.243965843959844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}