{"id":"W3014292260","doi":"10.1101/2020.04.02.021469","title":"LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health; National Natural Science Foundation of China","keywords":"Biology; Viral entry; Virology; Virus; HEK 293 cells; clone (Java method); Coronavirus; Gene knockdown; Tropism; Cell culture; Host factor; Cell biology; Viral replication; Genetics; Gene; Coronavirus disease 2019 (COVID-19); Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000122021,0.0001992099,0.000250318,0.0001164627,0.0001041046,0.0002638509,0.000114032,0.00020388,0.0009059401],"category_scores_gemma":[0.0001287125,0.00007205837,0.0001894425,0.00009634989,0.0001573459,0.0001474576,0.0001752686,0.0003075665,0.0004037801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539433,"about_ca_system_score_gemma":0.000154707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005020789,"about_ca_topic_score_gemma":0.0008120826,"domain_scores_codex":[0.9998858,0.00002347236,0.00001200461,0.00001784219,0.00003210364,0.00002874279],"domain_scores_gemma":[0.9999195,0.00002196703,0.00001194557,0.00001532979,0.0000110698,0.0000201138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007557195,0.00002238441,0.0001415401,0.00001521619,0.000001877018,0.0000158728,0.000006931134,0.00002525152,0.9992335,0.00001916363,0.00002176352,0.0004209548],"study_design_scores_gemma":[0.00001695252,0.0005125018,0.007443454,0.00000455895,0.000006695665,0.0002839918,0.00003034569,0.0009568469,0.9886098,0.00001697688,0.002114533,0.000003407213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971463,0.0008384785,0.0007315812,0.00005851637,0.00001109358,0.00001608678,0.0002073713,0.00004085393,0.0009497129],"genre_scores_gemma":[0.9957759,0.0004007859,0.00121309,0.00003272328,0.000006436275,0.00001852031,0.0005307216,0.00001443232,0.002007412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009059401,"threshold_uncertainty_score":0.003030658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1151880035893396,"score_gpt":0.3572504526618956,"score_spread":0.242062449072556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}