{"id":"W3014331947","doi":"10.1002/ejoc.202000424","title":"Expedient Pd‐Catalyzed α‐Arylation towards Dibenzoxepinones: Pivotal Manske's Ketone for the Formal Synthesis of Cularine Alkaloids","year":2020,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Synthesis of Organic Compounds","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Ketone; Catalysis; Formal synthesis; Total synthesis; Xanthone; Ring (chemistry); Combinatorial chemistry; Methyl Ketone; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485854,0.0005112884,0.0001843364,0.0002139873,0.0001473446,0.0001405112,0.0002675224,0.0001912399,0.001146325],"category_scores_gemma":[0.0001291501,0.0001087595,0.0001559183,0.000160162,0.000206865,0.0003220998,0.0003998606,0.0004412167,0.0005116079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001851221,"about_ca_system_score_gemma":0.0002945311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003954964,"about_ca_topic_score_gemma":0.001305809,"domain_scores_codex":[0.9999123,0.00001503258,0.000009548687,0.00001729911,0.00001743421,0.000028482],"domain_scores_gemma":[0.9999613,0.000006352003,0.000008949086,0.000007506577,0.000005986517,0.00001001742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001922353,0.0001140112,0.0003286505,0.0004708352,0.00002828348,0.0007310724,0.000232991,0.0008716992,0.9646803,0.00269614,0.0003793009,0.02927442],"study_design_scores_gemma":[0.00005042565,0.0007514766,0.001597673,0.00002289546,0.00003168666,0.0007876624,0.00006164103,0.001458398,0.9814559,0.0005158227,0.013243,0.00002325739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9062254,0.004610905,0.06151346,0.0003189758,0.0001462785,0.0002688421,0.0005003361,0.0002767219,0.0261391],"genre_scores_gemma":[0.9871219,0.002514786,0.006704795,0.00004313608,0.00001536138,0.00003485529,0.0001304146,0.00001609516,0.00341862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146325,"threshold_uncertainty_score":0.003834784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100628266936538,"score_gpt":0.2356462330568712,"score_spread":0.2146399503875058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}