{"id":"W3014348002","doi":"10.1016/j.eururo.2020.03.001","title":"The Oral Gonadotropin-releasing Hormone Receptor Antagonist Relugolix as Neoadjuvant/Adjuvant Androgen Deprivation Therapy to External Beam Radiotherapy in Patients with Localised Intermediate-risk Prostate Cancer: A Randomised, Open-label, Parallel-group Phase 2 Trial","year":2020,"lang":"en","type":"article","venue":"European Urology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Myovant Sciences; National Institute for Health and Care Research; Cancer Research UK","keywords":"Medicine; Prostate cancer; Androgen deprivation therapy; Urology; External beam radiotherapy; Castration; Clinical endpoint; Goserelin; Radiation therapy; Internal medicine; Oncology; Randomized controlled trial; Cancer; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004293709,0.0004336587,0.0007895044,0.00008955496,0.0002606385,0.0001678519,0.0004356546,0.00006655056,0.0000557133],"category_scores_gemma":[0.0001768532,0.0002773846,0.00008070884,0.0003247726,0.0002033584,0.0001633403,0.0001115692,0.0004048571,0.00004430697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002477085,"about_ca_system_score_gemma":0.0001976031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003530565,"about_ca_topic_score_gemma":0.00003775587,"domain_scores_codex":[0.9966373,0.0007958793,0.0008244858,0.0007956627,0.000332242,0.000614461],"domain_scores_gemma":[0.9983981,0.0001797403,0.0004584707,0.0004256609,0.0001226285,0.000415346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7501712,0.001772936,0.03742681,0.000008206385,0.0003661629,0.0002149634,0.00137572,0.0001252755,0.002808038,0.00001110957,0.001354191,0.2043654],"study_design_scores_gemma":[0.8320434,0.05128161,0.06479342,0.00008381384,0.0001359638,0.000009401007,0.00004782451,0.0003076769,0.0005314228,0.00001148087,0.05036315,0.0003908055],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814643,0.00624728,0.0004228653,0.004321753,0.000338088,0.006978744,0.0001135141,0.00006693131,0.00004652822],"genre_scores_gemma":[0.9654314,0.02507793,0.0007013314,0.007299499,0.000412533,0.0006821491,0.0002324662,0.00013709,0.00002563009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2039746,"threshold_uncertainty_score":0.9999678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02050125745166244,"score_gpt":0.2917673092677259,"score_spread":0.2712660518160634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}