{"id":"W3014418129","doi":"10.1089/biores.2020.0004","title":"Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs","year":2020,"lang":"en","type":"review","venue":"BioResearch open access","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Eye Institute","keywords":"Klotho; Remyelination; Neuroscience; Medicine; Myelin; Disease; Bioinformatics; Central nervous system; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004662319,0.0008437298,0.0009020186,0.002270112,0.0004067811,0.001193002,0.0007784813,0.001194402,0.006855147],"category_scores_gemma":[0.0007024947,0.0001964739,0.0003642567,0.002099493,0.0008372451,0.00155454,0.0009945001,0.002180985,0.003365064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007805203,"about_ca_system_score_gemma":0.000861946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009923989,"about_ca_topic_score_gemma":0.002350221,"domain_scores_codex":[0.9998366,0.00002682995,0.00001570633,0.00002722702,0.00007238713,0.00002130371],"domain_scores_gemma":[0.9997484,0.0001211332,0.00002554806,0.00001181158,0.00005603877,0.00003707407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006755474,0.00008237245,0.0001528104,0.007751789,0.00004703599,0.0002992555,0.00009571232,0.0002591778,0.002360887,0.01287358,0.05755432,0.9184555],"study_design_scores_gemma":[0.000005078998,0.0000276127,0.000249296,0.001035979,0.00002152178,0.000636494,0.00003690248,0.00002959968,0.0003450282,0.002913594,0.9946914,0.000007549022],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009752004,0.9962991,0.0001360821,0.0004794144,0.00043823,0.00000318098,0.00001625931,0.00001634471,0.002513875],"genre_scores_gemma":[0.000834177,0.9956225,0.0001877746,0.0003610397,0.0003912398,0.000006498219,0.00003650509,0.00000370751,0.002556604],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006855147,"threshold_uncertainty_score":0.02293277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09038504095882766,"score_gpt":0.4274082378826261,"score_spread":0.3370231969237984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}