{"id":"W3014418129","doi":"10.1089/biores.2020.0004","title":"Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs","year":2020,"lang":"en","type":"review","venue":"BioResearch open access","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Eye Institute","keywords":"Klotho; Remyelination; Neuroscience; Medicine; Myelin; Disease; Bioinformatics; Central nervous system; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication"],"consensus_categories":[],"category_scores_codex":[0.0003432752,0.0004878595,0.0008898061,0.0001375196,0.0002564825,0.001487079,0.002605266,0.0002715028,0.0000743761],"category_scores_gemma":[0.0003460692,0.0004159852,0.0002238522,0.0004064413,0.0001682952,0.00003036271,0.006781659,0.0003037347,0.00003689417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003349515,"about_ca_system_score_gemma":0.0007396239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001067588,"about_ca_topic_score_gemma":0.00002846942,"domain_scores_codex":[0.996814,0.0005548348,0.0004992407,0.001245493,0.0003658536,0.0005205581],"domain_scores_gemma":[0.9985155,0.0000585162,0.0002469846,0.0006579938,0.0001197628,0.0004012093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006857254,0.00005871534,0.0001949202,0.001825085,0.0001028152,0.000004443322,0.00002112135,7.326607e-7,0.0001337136,0.00005269048,0.001722912,0.995876],"study_design_scores_gemma":[0.0003088799,0.0002381368,0.001198475,0.0005707556,0.0001289463,0.00001041887,0.00002568428,0.00003375802,0.0001139601,0.00009093179,0.9967771,0.0005029821],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005421296,0.9956415,0.0001873611,0.0002342201,0.0001631627,0.002248335,0.0003122863,0.00001420964,0.0006568144],"genre_scores_gemma":[0.001788752,0.9955806,0.0002620468,0.00007909462,0.0003757516,0.0004329736,0.0008749668,0.0001088237,0.0004969478],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.995373,"threshold_uncertainty_score":0.9998292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09038504095882766,"score_gpt":0.4274082378826261,"score_spread":0.3370231969237984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}