{"id":"W3014440652","doi":"10.1111/his.14109","title":"Performance of the pattern‐based interpretation of p53 immunohistochemistry as a surrogate for <i>TP53</i> mutations in vulvar squamous cell carcinoma","year":2020,"lang":"en","type":"article","venue":"Histopathology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Immunohistochemistry; Mutation; Pathology; Oncology; Internal medicine; Biology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01719907,0.0006172395,0.0005154575,0.001897912,0.0004667902,0.001520701,0.0007967857,0.0009766606,0.0007252666],"category_scores_gemma":[0.03852138,0.000542219,0.0005844003,0.0006514619,0.0009202518,0.0009392948,0.001324413,0.0004163647,0.000602784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005395925,"about_ca_system_score_gemma":0.0003496659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001326258,"about_ca_topic_score_gemma":0.00137144,"domain_scores_codex":[0.9884184,0.005394381,0.001777382,0.001973333,0.002047248,0.0003893585],"domain_scores_gemma":[0.9725792,0.01394016,0.003390514,0.003395805,0.006040701,0.0006536375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002110922,0.00005510843,0.9381722,0.0001971513,0.0004443496,0.0002008271,0.0008751924,0.002007251,0.01740513,0.00009207414,0.0002923826,0.03814756],"study_design_scores_gemma":[0.00009720969,0.00138665,0.9318748,0.0001032982,0.0004569431,0.003147163,0.000834031,0.0345861,0.02583394,0.0005801383,0.001004747,0.00009496942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903548,0.0006898937,0.007299528,0.00004099552,0.00003936741,0.00003483478,0.00007103075,0.00006219566,0.001407405],"genre_scores_gemma":[0.9977945,0.00006539047,0.001936062,0.00001331892,0.000009370563,0.00001056579,0.00007892148,0.00001709749,0.00007477825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01719907,"threshold_uncertainty_score":0.09095848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009464841763699128,"score_gpt":0.237051392253474,"score_spread":0.2275865504897749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}