{"id":"W3014445345","doi":"10.1186/s13148-020-00844-2","title":"Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study","year":2020,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Economic and Social Research Council; University of Bristol; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Medical Research Council; Wellcome Trust","keywords":"Human genetics; DNA methylation; Prospective cohort study; Medicine; Cohort; Cohort study; Population; Genetics; Demography; Pediatrics; Bioinformatics; Biology; Internal medicine; Environmental health; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001191886,0.0006566544,0.0007783222,0.001134192,0.0009350062,0.001225826,0.0008444589,0.0008170155,0.001841243],"category_scores_gemma":[0.003001987,0.001011566,0.001112658,0.002451029,0.0007115823,0.0006827494,0.001542636,0.001197759,0.0004585775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000973643,"about_ca_system_score_gemma":0.0007270267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0805961,"about_ca_topic_score_gemma":0.07978987,"domain_scores_codex":[0.9986046,0.0004364121,0.000168504,0.0003668647,0.0002279333,0.0001957023],"domain_scores_gemma":[0.9974357,0.0003344607,0.001083031,0.0004578002,0.0002750931,0.0004138678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006886289,0.00002182779,0.9988809,0.00001340781,0.0001015178,0.0001027364,0.000214605,0.00002534344,0.0001133546,0.0000125923,0.0001075232,0.0003373572],"study_design_scores_gemma":[0.000006636415,0.00004874924,0.9993887,0.00001132911,0.00003059407,0.0001533763,0.0001715545,0.00004373364,0.00001846646,0.000005382981,0.0001178398,0.000003617245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979346,0.0003193478,0.00009784459,0.00003414853,0.000008825316,0.00002214928,0.001399075,0.000003775169,0.0001803957],"genre_scores_gemma":[0.9978266,0.0004214013,0.0002203441,0.0000420947,0.000009837839,0.00005108379,0.001139674,0.000003973005,0.000284922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0805961,"threshold_uncertainty_score":0.1602539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02284494097101197,"score_gpt":0.3197192255497258,"score_spread":0.2968742845787138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}