{"id":"W3014447490","doi":"10.1016/j.ijpharm.2020.119292","title":"Evolution of supersaturation from amorphous solid dispersions in water-insoluble polymer carriers: Effects of swelling capacity and interplay between partition and diffusion","year":2020,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Supersaturation; Swelling; Solubility; Chemical engineering; Polymer; Swelling capacity; Dissolution; Chemistry; Vinyl alcohol; Drug carrier; Dosage form; Amorphous solid; Materials science; Organic chemistry; Chromatography; Drug delivery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00041733,0.0001493017,0.0003654507,0.0001833605,0.00005441474,0.00001957743,0.0001928332,0.0001785798,0.00005721694],"category_scores_gemma":[0.0001077215,0.0001295502,0.00008961309,0.0000895573,0.0001919249,0.0003491986,0.00009790561,0.0005452537,0.000002300993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001082378,"about_ca_system_score_gemma":0.00004501894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002387235,"about_ca_topic_score_gemma":0.00002257237,"domain_scores_codex":[0.9982717,0.000344386,0.0007418814,0.000161896,0.0003106515,0.0001694617],"domain_scores_gemma":[0.9986767,0.0004171173,0.0003894286,0.00005169934,0.0002567284,0.0002083238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000821121,0.0001700523,0.1602132,0.000150263,0.0003641694,0.0000366281,0.01022683,0.0007830185,0.8249807,0.0001038529,0.00004521979,0.002104847],"study_design_scores_gemma":[0.003284065,0.0002311494,0.01028566,0.0002463996,0.0003073391,0.00002861862,0.0009735021,0.03111466,0.9522486,0.0002467366,0.0008793758,0.0001539486],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939543,0.001638392,0.001984668,0.0008765599,0.001232015,0.000167095,0.0001073172,0.000008252163,0.00003138172],"genre_scores_gemma":[0.9984621,0.0007740325,0.00009133539,0.0002190716,0.0004115794,0.000001838812,0.00002329377,0.00001078748,0.00000600537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1499276,"threshold_uncertainty_score":0.5282905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06402343520390084,"score_gpt":0.3876382516941401,"score_spread":0.3236148164902393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}