{"id":"W3014505012","doi":"10.1038/s41379-020-0527-y","title":"p53 Immunohistochemical patterns in HPV-related neoplasms of the female lower genital tract can be mistaken for TP53 null or missense mutational patterns","year":2020,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Advancing Health Outcomes; Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Immunohistochemistry; Pathology; Staining; Biology; Vulva; In situ hybridization; Cervix; HPV infection; Intraepithelial neoplasia; Cancer; Medicine; Cervical cancer; Messenger RNA; Gene; Prostate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000144401,0.0001751083,0.000413944,0.00005919611,0.00004844252,0.000008103375,0.0002008308,0.0002168462,0.002192282],"category_scores_gemma":[0.0002957769,0.0001253264,0.0001990155,0.0001442261,0.0001452739,0.00002624727,0.00007679492,0.0004601661,0.000005999484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001181731,"about_ca_system_score_gemma":0.0002802504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001662924,"about_ca_topic_score_gemma":0.0003401118,"domain_scores_codex":[0.9983789,0.00008324124,0.000448564,0.0004007681,0.0003077505,0.0003807158],"domain_scores_gemma":[0.9990931,0.0002224329,0.00008773008,0.0002816617,0.0001520045,0.0001631427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03121302,0.004743534,0.3357705,0.003625748,0.0005550049,0.01106012,0.06126538,0.0007750485,0.4783261,0.0002876774,0.002170348,0.07020755],"study_design_scores_gemma":[0.02003051,0.003333832,0.9068227,0.0001036393,0.0003156923,0.002225199,0.001548672,0.02608347,0.03685518,0.0007144969,0.001239215,0.0007273776],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885889,0.0001300252,0.0009900506,0.008377735,0.0001130007,0.0006977249,0.0005746606,0.00002201814,0.0005058722],"genre_scores_gemma":[0.9973134,0.000009279249,0.0001159981,0.001710896,0.00009002901,0.00008457616,0.0001972334,0.00003757078,0.0004409573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5710523,"threshold_uncertainty_score":0.9987199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05449979731027508,"score_gpt":0.3242065407308091,"score_spread":0.269706743420534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}