{"id":"W3014505012","doi":"10.1038/s41379-020-0527-y","title":"p53 Immunohistochemical patterns in HPV-related neoplasms of the female lower genital tract can be mistaken for TP53 null or missense mutational patterns","year":2020,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Advancing Health Outcomes; Vancouver General Hospital; University of British Columbia","funders":"","keywords":"Immunohistochemistry; Pathology; Staining; Biology; Vulva; In situ hybridization; Cervix; HPV infection; Intraepithelial neoplasia; Cancer; Medicine; Cervical cancer; Messenger RNA; Gene; Prostate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000596569,0.0006494351,0.0002455118,0.00229472,0.000323287,0.0006668955,0.0005044006,0.0006729676,0.003052047],"category_scores_gemma":[0.002837652,0.0003577778,0.000255681,0.0008003985,0.0008659922,0.0007758493,0.0005602914,0.0003508663,0.001157102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678765,"about_ca_system_score_gemma":0.0001596305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004546415,"about_ca_topic_score_gemma":0.0006868666,"domain_scores_codex":[0.9996753,0.00005457317,0.00005161353,0.00005388724,0.00007336455,0.0000912993],"domain_scores_gemma":[0.9991297,0.0003185451,0.0002003194,0.0001149212,0.0001086677,0.0001279191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00138165,0.00009798169,0.354137,0.0004198642,0.0001034725,0.3135094,0.0005405547,0.0002893469,0.293114,0.0007652434,0.0009322328,0.03470929],"study_design_scores_gemma":[0.00003408241,0.0003331628,0.2510458,0.000114555,0.0002806432,0.6609204,0.001052515,0.002300648,0.07805538,0.001531876,0.00430124,0.0000296668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886767,0.001836422,0.00311023,0.0002199268,0.00009042562,0.00002291161,0.00009078257,0.0001085735,0.005844002],"genre_scores_gemma":[0.9976293,0.0006747996,0.00112295,0.00004680442,0.00002635937,0.000004026857,0.0000403998,0.00001677193,0.0004385219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003052047,"threshold_uncertainty_score":0.01021016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05449979731027508,"score_gpt":0.3242065407308091,"score_spread":0.269706743420534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}