{"id":"W3014518127","doi":"10.1186/s13148-020-00840-6","title":"DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes","year":2020,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Hospital for Sick Children; Public Health Ontario; SickKids Foundation; University of Toronto; McMaster University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Medicine; dNaM; Diabetes mellitus; Internal medicine; Diabetic retinopathy; Population; Diabetic nephropathy; Retinopathy; Type 2 diabetes; Type 1 diabetes; Epidemiology; Nephropathy; Endocrinology; DNA methylation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008852534,0.0003266612,0.0002841961,0.0009834793,0.0001723634,0.0004790761,0.0002784437,0.0003260352,0.001779935],"category_scores_gemma":[0.002856716,0.0001707961,0.0003877814,0.001214712,0.0001154018,0.0002014109,0.0003307526,0.0004746508,0.0003054794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002505596,"about_ca_system_score_gemma":0.0001427005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002553202,"about_ca_topic_score_gemma":0.003331857,"domain_scores_codex":[0.9996159,0.0001250455,0.00003517364,0.0001280634,0.00007008254,0.0000257729],"domain_scores_gemma":[0.9982557,0.0006004809,0.0006672137,0.0001560621,0.0002276431,0.00009292003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004902602,0.0000280005,0.9838468,0.00004138206,0.0001497106,0.00002274758,0.00005059614,0.000279994,0.001052025,0.00002777969,0.0001914111,0.01381928],"study_design_scores_gemma":[0.00001106898,0.0001254151,0.9961448,0.0000174426,0.0001477496,0.0001458086,0.00005100848,0.001725101,0.0009666891,0.0001356462,0.0005207219,0.000008550264],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913288,0.002574233,0.002836209,0.00007835663,0.00002458146,0.00002399656,0.001599915,0.0001062081,0.001427781],"genre_scores_gemma":[0.9953561,0.0003958933,0.002810273,0.00003944524,0.00001571182,0.00002676926,0.000676367,0.00001409985,0.0006654033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002553202,"threshold_uncertainty_score":0.005954504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326631883177393,"score_gpt":0.3055921445345133,"score_spread":0.2723258257027393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}